Akkermansia muciniphila ameliorates acetaminophen-induced liver injury by regulating gut microbial composition and metabolism

J Xia, L Lv, B Liu, S Wang, S Zhang, Z Wu… - Microbiology …, 2022 - Am Soc Microbiol
The gut microbiota drives individual sensitivity to excess acetaminophen (APAP)-mediated
hepatotoxicity. It has been reported that the bacterium Akkermansia muciniphila protects …

Protective Effect of Akkermansia muciniphila against Immune-Mediated Liver Injury in a Mouse Model

W Wu, L Lv, D Shi, J Ye, D Fang, F Guo, Y Li… - Frontiers in …, 2017 - frontiersin.org
Accumulating evidence indicates that gut microbiota participates in the pathogenesis and
progression of liver diseases. The severity of immune-mediated liver injury is associated …

The protective effects of live and pasteurized Akkermansia muciniphila and its extracellular vesicles against HFD/CCl4-induced liver injury

S Keshavarz Azizi Raftar, F Ashrafian… - Microbiology …, 2021 - Am Soc Microbiol
Akkermansia muciniphila, as a member of the gut microbiota, has been proposed as a next-
generation probiotic. Liver fibrosis is the main determinant of liver dysfunction and mortality …

Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis

Y Rao, Z Kuang, C Li, S Guo, Y Xu, D Zhao, Y Hu… - Gut …, 2021 - Taylor & Francis
The gut bacterium Akkermansia muciniphila has been increasingly recognized for its
therapeutic potential in treating metabolic disorders, including obesity, diabetes, and …

The anti-inflammatory effects of Akkermansia muciniphila and its derivates in HFD/CCL4-induced murine model of liver injury

SKA Raftar, F Ashrafian, S Abdollahiyan, A Yadegar… - Scientific Reports, 2022 - nature.com
Inflammation plays a critical role in the promotion of hepatocyte damage and liver fibrosis. In
recent years the protective role of Akkermansia muciniphila, a next-generation beneficial …

Akkermansia muciniphila attenuated lipopolysaccharide-induced acute lung injury by modulating the gut microbiota and SCFAs in mice

J Shen, S Wang, H Xia, S Han, Q Wang, Z Wu… - Food & Function, 2023 - pubs.rsc.org
Gut microbiota are closely related to lipopolysaccharide (LPS)-induced acute lung injury
(ALI). Akkermansia muciniphila (A. muciniphila) maintains the intestinal barrier function and …

Akkermansia muciniphila alleviates high‐fat‐diet‐related metabolic‐associated fatty liver disease by modulating gut microbiota and bile acids

W Wu, W Kaicen, X Bian, L Yang, S Ding… - Microbial …, 2023 - Wiley Online Library
It has been reported that Akkermansia muciniphila improves host metabolism and reduces
inflammation; however, its potential effects on bile acid metabolism and metabolic patterns …

Akkermansia muciniphila inhibits nonalcoholic steatohepatitis by orchestrating TLR2-activated γδT17 cell and macrophage polarization

Y Han, Q Ling, L Wu, X Wang, Z Wang, J Chen… - Gut …, 2023 - Taylor & Francis
Current evidence indicates that the next-generation probiotic Akkermansia muciniphila (A.
muciniphila) has therapeutic potential for nonalcoholic fatty liver disease (NAFLD) …

The Synbiotic Combination of Akkermansia muciniphila and Quercetin Ameliorates Early Obesity and NAFLD through Gut Microbiota Reshaping and Bile Acid …

M Juárez-Fernández, D Porras, P Petrov… - Antioxidants, 2021 - mdpi.com
Gut microbiota plays a key role in obesity and non-alcoholic fatty liver disease (NAFLD), so
synbiotics could be a therapeutic alternative. We aim to evaluate a nutritional intervention …

[HTML][HTML] Bifidobacterium longum R0175 protects mice against APAP-induced liver injury by modulating the Nrf2 pathway

S Li, A Zhuge, J Xia, S Wang, L Lv, K Wang… - Free Radical Biology …, 2023 - Elsevier
Acetaminophen (APAP) overdose is the most common driver of drug-induced liver injury
(DILI) worldwide, and the gut microbiome plays a crucial role in this process. In this study …