Hyperbaric oxygen therapy improves Parkinson's disease by promoting mitochondrial biogenesis via the SIRT-1/PGC-1α pathway

HT Hsu, YL Yang, WH Chang, WY Fang, SH Huang… - Biomolecules, 2022 - mdpi.com
Hyperbaric oxygen therapy (HBOT) has been suggested as a potential adjunctive therapy
for Parkinson's disease (PD). PD is a neurodegenerative disease characterized by the …

2-Aminoethoxydiphenyl borate ameliorates mitochondrial dysfunctions in MPTP/MPP+ model of Parkinson's disease

B Vaidya, M Polepalli, SS Sharma, JN Singh - Mitochondrion, 2023 - Elsevier
Mitochondrial dysfunction is closely linked with the pathophysiology of several
neurodegenerative disorders including Parkinson's disease (PD). Despite several …

Prophylactic treatment of hyperbaric oxygen treatment mitigates inflammatory response via mitochondria transfer

T Lippert, CV Borlongan - CNS neuroscience & therapeutics, 2019 - Wiley Online Library
Aims Hyperbaric oxygen therapy (HBOT) has been widely used as postinjury treatment;
however, we investigate its ability to mitigate potential damage as a preconditioning option …

Hyperbaric oxygen alleviated cognitive impairments in mice induced by repeated cerebral ischemia-reperfusion injury via inhibition of autophagy

C Chen, W Chen, Z Nong, Y Nie, X Chen, X Pan, Y Guo… - Life Sciences, 2020 - Elsevier
Aims In this study, we investigate the effect and underlying mechanism of hyperbaric oxygen
(HBO) treatment on a model of repeated cerebral ischemia-reperfusion injury (IR). Main …

Hyperbaric oxygen preconditioning reduces ischemia–reperfusion injury by inhibition of apoptosis via mitochondrial pathway in rat brain

JS Li, W Zhang, ZM Kang, SJ Ding, WW Liu, JH Zhang… - Neuroscience, 2009 - Elsevier
This study examined the hypothesis that apoptotic inhibition via mitochondrial pathway was
involved in hyperbaric oxygen preconditioning (HBO-PC)–induced neuroprotection on …

Hyperbaric oxygen therapy alleviates memory and motor impairments following traumatic brain injury via the modulation of mitochondrial-dysfunction-induced …

R Sakas, K Dan, D Edelman, S Abu-Ata… - Antioxidants, 2023 - mdpi.com
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young adults,
characterized by primary and secondary injury. Primary injury is the immediate mechanical …

Hyperbaric oxygen protects against myocardial ischemia‑reperfusion injury through inhibiting mitochondria dysfunction and autophagy

W Chen, L Lv, Z Nong, X Chen… - Molecular Medicine …, 2020 - spandidos-publications.com
Our previous study demonstrated that hyperbaric oxygen (HBO) improves heart function
predominantly through reducing oxygen stress, modulating energy metabolism and …

Neuroprotective effect of anodal transcranial direct current stimulation on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity in mice through …

SB Lee, J Youn, W Jang, HO Yang - Neurochemistry International, 2019 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the
accumulation of protein inclusions and the loss of dopaminergic neurons. Abnormal …

Modulation of mitochondrial phenotypes by endurance exercise contributes to neuroprotection against a MPTP-induced animal model of PD

Y Jang, I Kwon, W Song, LM Cosio-Lima, S Taylor… - Life Sciences, 2018 - Elsevier
Aim Endurance exercise (EE) has been reported to confer neuroprotection against
Parkinson's disease (PD); however, underlying molecular mechanisms of the protection …

Neuroprotective effect of hyperbaric oxygen therapy in brain injury is mediated by preservation of mitochondrial membrane properties

E Palzur, M Zaaroor, E Vlodavsky, F Milman… - Brain research, 2008 - Elsevier
Recent experimental data have shown that hyperbaric oxygen therapy (HBOT) was
associated increased Bcl-2 expression at the injury site that correlated with reduced …