Acylation of biomolecules (eg, proteins and small molecules) is a process that occurs in cells
of all domains of life and has emerged as a critical mechanism for the control of many …

ABSTRACT N ε-Lysine acetylation is now recognized as an abundant posttranslational
modification (PTM) that influences many essential biological pathways. Advancements in …

Protein acetylation plays a critical regulatory role in eukaryotes but until recently its
significance and function in bacteria and the archaea were obscure. It is now clear, however …

Post-translational modification of proteins is a reversible mechanism of cellular adaptation to
changing environmental conditions. In eukaryotes, the physiological relevance of N-ɛ-lysine …

Acetylation is a posttranslational modification conserved in all domains of life that is carried
out by N-acetyltransferases. While acetylation can occur on N α-amino groups, this review …

Protein acetylation has historically been considered a predominantly eukaryotic
phenomenon. Recent evidence, however, supports the hypothesis that acetylation broadly …

Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity
to an existing proteome. The large number of known PTMs highlights the many ways that …

Acetylation of lysine residues is conserved in all three kingdoms; however, its role in
prokaryotes is unknown. Here we demonstrate that acetylation enables the reference …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Highlights•Epigenetic methylation and acetylation are sensitive to cellular metabolic
status.•Diet and environment conditions shape epigenetics through metabolism.•Stem cells …