Effect of long-acting injectable antipsychotics vs usual care on time to first hospitalization in early-phase schizophrenia: a randomized clinical trial

JM Kane, NR Schooler, P Marcy, CU Correll… - JAMA …, 2020 - jamanetwork.com
Importance Long-acting injectable antipsychotics (LAIs) can potentially reduce
hospitalization risk by enhancing medication adherence but are rarely considered for early …

Clinical benefits and impact of early use of long‐acting injectable antipsychotics for schizophrenia

GL Stevens, G Dawson, J Zummo - Early intervention in …, 2016 - Wiley Online Library
Aim Results from clinical trials support the use of oral antipsychotics for treatment of early or
first‐episode psychosis in patients with schizophrenia. This paper will review literature on …

Patients with early-phase schizophrenia will accept treatment with sustained-release medication (long-acting injectable antipsychotics): results from the recruitment …

JM Kane, NR Schooler, P Marcy… - The Journal of clinical …, 2019 - psychiatrist.com
Objective: To document the acceptability of treatment with long-acting injectable (LAI)
antipsychotic medication to early-phase schizophrenia patients as demonstrated by …

Effectiveness of long-acting injectable vs oral antipsychotics in patients with schizophrenia: a meta-analysis of prospective and retrospective cohort studies

T Kishimoto, K Hagi, M Nitta, S Leucht… - Schizophrenia …, 2018 - academic.oup.com
Compared with oral antipsychotics (OAPs), long-acting injectable antipsychotics (LAIs)
should improve medication adherence and reduce relapses in schizophrenia. However …

20-year nationwide follow-up study on discontinuation of antipsychotic treatment in first-episode schizophrenia

J Tiihonen, A Tanskanen… - American Journal of …, 2018 - Am Psychiatric Assoc
Objective: It is generally believed that after the first episode of schizophrenia, the risk of
relapse decreases with time in patients who are stabilized. Many treatment guidelines …

[HTML][HTML] Long-acting injectable antipsychotics in schizophrenia: literature review and practical perspective, with a focus on aripiprazole once-monthly

E Biagi, E Capuzzi, F Colmegna, A Mascarini… - Advances in …, 2017 - Springer
Introduction Prevention of relapse is a major challenge in schizophrenia, a disease
characterized by poor adherence to antipsychotic medication leading to multiple …

Antipsychotic adherence and rehospitalization in schizophrenia patients receiving oral versus long-acting injectable antipsychotics following hospital discharge

SC Marcus, J Zummo, AR Pettit, J Stoddard… - Journal of managed …, 2015 - jmcp.org
BACKGROUND: Antipsychotic medications are a central component of effective treatment
for schizophrenia, but nonadherence is a significant problem for the majority of patients …

The effect of longer dosing intervals for long-acting injectable antipsychotics on outcomes in schizophrenia

R Milz, C Benson, K Knight, J Antunes… - Neuropsychiatric …, 2023 - Taylor & Francis
Medication nonadherence in schizophrenia can have serious implications including
relapses and hospitalization. Long-acting injectable (LAI) antipsychotics require fewer …

[HTML][HTML] Impact of atypical long-acting injectable versus oral antipsychotics on rehospitalization rates and emergency room visits among relapsed schizophrenia …

MH Lafeuille, F Laliberté-Auger, P Lefebvre, C Frois… - BMC psychiatry, 2013 - Springer
Background Among schizophrenia patients relapsed on an oral antipsychotic (AP), this
study compared the impact of switching to atypical AP long-acting injectable therapy (LAT) …

Comparison of SGA oral medications and a long-acting injectable SGA: the PROACTIVE study

PF Buckley, NR Schooler, DC Goff, J Hsiao… - Schizophrenia …, 2015 - academic.oup.com
Until relatively recently, long-acting injectable (LAI) formulations were only available for first-
generation antipsychotics and their utilization decreased as use of oral second-generation …