Due to commonalities in pathophysiology, age-related macular degeneration (AMD)
represents a uniquely accessible model to investigate therapies for neurodegenerative …

Oxidative damage and inflammation are postulated to be involved in age-related macular
degeneration (AMD). However, the molecular signal (s) linking oxidation to inflammation in …

Age-related macular degeneration (AMD) is the leading cause of vision loss and visual
impairment in people over 50 years of age. In the current therapeutic landscape, intravitreal …

The recent paradigm shift that microglia are yolk sac-derived, not hematopoietic-derived, is
reshaping our knowledge about the isolated role of microglia in CNS diseases, including …

Genome-wide association studies (GWAS) have identified genetic variants associated with
age-related macular degeneration (AMD), one of the leading causes of blindness in the …

In dry age-related macular degeneration (AMD), inflammation plays a key role in disease
pathogenesis. Innate immune cells such as microglia and neutrophils infiltrate the sub …

Age-related macular degeneration (AMD) is a disease of the outer retina, characterized most
significantly by atrophy of photoreceptors and retinal pigment epithelium accompanied with …

Age‐related macular degeneration (AMD) is a blinding eye disease with no unifying theme
for its etiology. We used single-cell RNA sequencing to analyze the transcriptomes of …

Background Age-related macular degeneration (AMD) is a leading cause of blindness that
affects the central region of the retinal pigmented epithelium (RPE), choroid, and neural …

Inflammation protects from dangerous stimuli, restoring normal tissue homeostasis.
Inflammatory response in the nervous system (“neuroinflammation”) has distinct features …