Novel flavonoid 1, 3, 4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway
HW Meng, ZB Shen, XS Meng, ZQ Yin, XR Wang… - Bioorganic …, 2023 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder with a complex
etiology. Neuroinflammation and oxidative stress are important factors driving the …
etiology. Neuroinflammation and oxidative stress are important factors driving the …
Design, synthesis, and SAR study of novel flavone 1, 2, 4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease
ZB Shen, HW Meng, XS Meng, ZK Lv, MY Fang… - European Journal of …, 2023 - Elsevier
Inflammation is one of a major feature of Parkinson's disease (PD) which poses a threat to
people's health in the world. It has been reported that antioxidation and anti-inflammation …
people's health in the world. It has been reported that antioxidation and anti-inflammation …
5-(3, 4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1, 2, 4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute …
LL Xu, YF Wu, F Yan, CC Li, Z Dai, QD You… - Free Radical Biology …, 2019 - Elsevier
Parkinson's disease (PD) is the second most common aging-related neurodegenerative
disease worldwide. Oxidative stress and neuroinflammation are critical events in the …
disease worldwide. Oxidative stress and neuroinflammation are critical events in the …
Vitamin E analog trolox attenuates MPTP-induced Parkinson's disease in mice, mitigating oxidative stress, neuroinflammation, and motor impairment
A Atiq, HJ Lee, A Khan, MH Kang, IU Rehman… - International Journal of …, 2023 - mdpi.com
Trolox is a potent antioxidant and a water-soluble analog of vitamin E. It has been used in
scientific studies to examine oxidative stress and its impact on biological systems. Trolox has …
scientific studies to examine oxidative stress and its impact on biological systems. Trolox has …
Investigating therapeutic effects of indole derivatives targeting inflammation and oxidative stress in neurotoxin-induced cell and mouse models of Parkinson's disease
YJ Chiu, CH Lin, CY Lin, PN Yang, YS Lo… - International journal of …, 2023 - mdpi.com
Neuroinflammation and oxidative stress have been emerging as important pathways
contributing to Parkinson's disease (PD) pathogenesis. In PD brains, the activated microglia …
contributing to Parkinson's disease (PD) pathogenesis. In PD brains, the activated microglia …
Wuzi Yanzong Pill relieves MPTP-induced motor dysfunction and neuron loss by inhibiting NLRP3 inflammasome-mediated neuroinflammation
T Pan, Q Xiao, HJ Fan, L Xu, SC Qin, LX Yang… - Metabolic Brain …, 2023 - Springer
Parkinson disease (PD) is an age-related neurodegenerative disease, which is associated
with the loss of dopaminergic neurons (DA neurons) in the substantia nigra pars compacta …
with the loss of dopaminergic neurons (DA neurons) in the substantia nigra pars compacta …
α-Cyperone protects dopaminergic neurons and inhibits neuroinflammation in LPS-induced Parkinson's disease rat model via activating Nrf2/HO-1 and suppressing …
B Huang, G Hu, X Zong, S Yang, D He, X Gao… - International …, 2023 - Elsevier
Our previous study showed that α-Cyperone inhibited the inflammatory response triggered
by activated microglia and protected dopaminergic neuron in in vitro cell model of …
by activated microglia and protected dopaminergic neuron in in vitro cell model of …
CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response …
RL Jayaraj, N Elangovan, C Dhanalakshmi… - Chemico-Biological …, 2014 - Elsevier
Parkinson's disease (PD) is characterized by the progressive degeneration via apoptosis of
nigrostriatal dopaminergic neurons associated with inflammation, resulting in behavioral …
nigrostriatal dopaminergic neurons associated with inflammation, resulting in behavioral …
Berberine protects against NLRP3 inflammasome via ameliorating autophagic impairment in MPTP-induced Parkinson's disease model
S Huang, H Liu, Y Lin, M Liu, Y Li, H Mao… - Frontiers in …, 2021 - frontiersin.org
The NLR family pyrin domain containing 3 (NLRP3) inflammasome was reported to be
regulated by autophagy and activated during inflammatory procession of Parkinson's …
regulated by autophagy and activated during inflammatory procession of Parkinson's …
Triple herbal extract DA-9805 exerts a neuroprotective effect via amelioration of mitochondrial damage in experimental models of Parkinson's disease
Abstract Moutan cortex, Angelica Dahurica root, and Bupleurum root are traditional herbal
medicines used in Asian countries to treat various diseases caused by oxidative stress or …
medicines used in Asian countries to treat various diseases caused by oxidative stress or …
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