Novel flavonoid 1, 3, 4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway

HW Meng, ZB Shen, XS Meng, ZQ Yin, XR Wang… - Bioorganic …, 2023 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder with a complex
etiology. Neuroinflammation and oxidative stress are important factors driving the …

Design, synthesis, and SAR study of novel flavone 1, 2, 4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease

ZB Shen, HW Meng, XS Meng, ZK Lv, MY Fang… - European Journal of …, 2023 - Elsevier
Inflammation is one of a major feature of Parkinson's disease (PD) which poses a threat to
people's health in the world. It has been reported that antioxidation and anti-inflammation …

5-(3, 4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1, 2, 4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute …

LL Xu, YF Wu, F Yan, CC Li, Z Dai, QD You… - Free Radical Biology …, 2019 - Elsevier
Parkinson's disease (PD) is the second most common aging-related neurodegenerative
disease worldwide. Oxidative stress and neuroinflammation are critical events in the …

Vitamin E analog trolox attenuates MPTP-induced Parkinson's disease in mice, mitigating oxidative stress, neuroinflammation, and motor impairment

A Atiq, HJ Lee, A Khan, MH Kang, IU Rehman… - International Journal of …, 2023 - mdpi.com
Trolox is a potent antioxidant and a water-soluble analog of vitamin E. It has been used in
scientific studies to examine oxidative stress and its impact on biological systems. Trolox has …

Investigating therapeutic effects of indole derivatives targeting inflammation and oxidative stress in neurotoxin-induced cell and mouse models of Parkinson's disease

YJ Chiu, CH Lin, CY Lin, PN Yang, YS Lo… - International journal of …, 2023 - mdpi.com
Neuroinflammation and oxidative stress have been emerging as important pathways
contributing to Parkinson's disease (PD) pathogenesis. In PD brains, the activated microglia …

Wuzi Yanzong Pill relieves MPTP-induced motor dysfunction and neuron loss by inhibiting NLRP3 inflammasome-mediated neuroinflammation

T Pan, Q Xiao, HJ Fan, L Xu, SC Qin, LX Yang… - Metabolic Brain …, 2023 - Springer
Parkinson disease (PD) is an age-related neurodegenerative disease, which is associated
with the loss of dopaminergic neurons (DA neurons) in the substantia nigra pars compacta …

α-Cyperone protects dopaminergic neurons and inhibits neuroinflammation in LPS-induced Parkinson's disease rat model via activating Nrf2/HO-1 and suppressing …

B Huang, G Hu, X Zong, S Yang, D He, X Gao… - International …, 2023 - Elsevier
Our previous study showed that α-Cyperone inhibited the inflammatory response triggered
by activated microglia and protected dopaminergic neuron in in vitro cell model of …

CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response …

RL Jayaraj, N Elangovan, C Dhanalakshmi… - Chemico-Biological …, 2014 - Elsevier
Parkinson's disease (PD) is characterized by the progressive degeneration via apoptosis of
nigrostriatal dopaminergic neurons associated with inflammation, resulting in behavioral …

Berberine protects against NLRP3 inflammasome via ameliorating autophagic impairment in MPTP-induced Parkinson's disease model

S Huang, H Liu, Y Lin, M Liu, Y Li, H Mao… - Frontiers in …, 2021 - frontiersin.org
The NLR family pyrin domain containing 3 (NLRP3) inflammasome was reported to be
regulated by autophagy and activated during inflammatory procession of Parkinson's …

Triple herbal extract DA-9805 exerts a neuroprotective effect via amelioration of mitochondrial damage in experimental models of Parkinson's disease

JS Jeong, Y Piao, S Kang, M Son, YC Kang, XF Du… - Scientific reports, 2018 - nature.com
Abstract Moutan cortex, Angelica Dahurica root, and Bupleurum root are traditional herbal
medicines used in Asian countries to treat various diseases caused by oxidative stress or …