Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like phenotype specific to the elevated plus-maze

KR Bailey, MN Pavlova, AD Rohde… - Pharmacology …, 2007 - Elsevier
The neuropeptide galanin has been implicated in anxiety-related behaviors, cognition,
analgesia, and feeding in rodents. Neuromodulatory actions of galanin are mediated by …

[HTML][HTML] Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-maze

A Holmes, JW Kinney, CC Wrenn, Q Li… - …, 2003 - nature.com
The neuropeptide galanin coexists with norepinephrine and serotonin in neural systems
mediating emotion. Previous findings suggested that galanin modulates anxiety-related …

GAL3 receptor KO mice exhibit an anxiety-like phenotype

SM Brunner, A Farzi, F Locker… - Proceedings of the …, 2014 - National Acad Sciences
The neuropeptide galanin (GAL) is widely distributed in the central and peripheral nervous
systems. It is a modulator of various physiological and pathological processes, and it …

Phenotypic analysis of GalR2 knockout mice in anxiety-and depression-related behavioral tests

X Lu, B Ross, M Sanchez-Alavez, EP Zorrilla, T Bartfai - Neuropeptides, 2008 - Elsevier
Neuropeptide galanin modulates a variety of central nervous system functions by signaling
through three G-protein-coupled receptor subtypes, GalR1 through GalR3. Galanin and its …

Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2)

ML Gottsch, H Zeng, JG Hohmann… - … and Cellular Biology, 2005 - Taylor & Francis
Galanin is a neuropeptide implicated in the regulation of feeding, reproduction, cognition,
nociception, and seizure susceptibility. There are three known galanin receptor (GALR) …

Learning and memory performance in mice lacking the GAL‐R1 subtype of galanin receptor

CC Wrenn, JW Kinney, LK Marriott… - European Journal of …, 2004 - Wiley Online Library
The neuropeptide galanin induces performance deficits in a wide range of cognitive tasks in
rodents. Three G‐protein‐coupled galanin receptor subtypes, designated GAL‐R1, GAL‐R2 …

Ectopic galanin expression and normal galanin receptor 2 and galanin receptor 3 mRNA levels in the forebrain of galanin transgenic mice

B He, SE Counts, SE Perez, JG Hohmann, JB Koprich… - Neuroscience, 2005 - Elsevier
The functional interactions of the neuropeptide galanin (GAL) occur through its binding to
three G protein-coupled receptor subtypes: galanin receptor (GALR) 1, GALR2 and GALR3 …

Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic mice

A Holmes, RJ Yang, JN Crawley - Journal of Molecular Neuroscience, 2002 - Springer
Understanding the role of neuropeptides in mediating emotional behaviors is an important
avenue for discovering novel drug targets for anxiety disorders. A role for galanin in …

Molecular cloning and characterization of a new receptor for galanin

AD Howard, C Tan, LL Shiao, OC Palyha… - FEBS …, 1997 - Wiley Online Library
Galanin (GAL) is a widely distributed neuropeptide with diverse biological effects including
modulation of hormone release, antinociception and modification of feeding behavior. Its …

Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity

X Lu, A Mazarati, P Sanna, S Shinmei, T Bartfai - Neuropeptides, 2005 - Elsevier
Galanin, acting at the GalR1-3 subtypes of galanin receptors, is involved in the regulation of
cognition, mood, feeding, seizure activity and pain. The understanding of galanin's effects in …