Tumor microenvironment targeted nanotherapeutics for cancer therapy and diagnosis: A review

S Thakkar, D Sharma, K Kalia, RK Tekade - Acta biomaterialia, 2020 - Elsevier
Recent findings suggest that the cellular and extracellular materials surrounding the
cancerous cells from an atypical tumor microenvironment (TM) play a pivotal role in the …

Tumour microenvironment responsive nanoconstructs for cancer theranostic

A Gulzar, J Xu, C Wang, F He, D Yang, S Gai, P Yang… - Nano today, 2019 - Elsevier
The tumour mass is made up of not only of a heterogeneous population of cancer cells
nonetheless also a mixture of resident as well as the infiltrating host cells, secreted factors …

Tumor microenvironment and nanotherapeutics: intruding the tumor fort

AVVVR Kiran, GK Kumari, PT Krishnamurthy… - Biomaterials …, 2021 - pubs.rsc.org
Over recent years, advancements in nanomedicine have allowed new approaches to
diagnose and treat tumors. Nano drug delivery systems exploit the enhanced permeability …

Tumor microenvironment-responsive nanoparticles for cancer theragnostic applications

S Uthaman, KM Huh, IK Park - Biomaterials research, 2018 - spj.science.org
Background Cancer is one of the deadliest threats to human health. Abnormal
physiochemical conditions and dysregulated biosynthetic intermediates in the tumor …

Nanomaterials in anticancer applications and their mechanism of action-A review

CGA Das, VG Kumar, TS Dhas, V Karthick… - … , Biology and Medicine, 2023 - Elsevier
The current challenges in cancer treatment using conventional therapies have made the
emergence of nanotechnology with more advancements. The exponential growth of …

Using functional nanomaterials to target and regulate the tumor microenvironment: diagnostic and therapeutic applications

T Ji, Y Zhao, Y Ding, G Nie - Advanced Materials, 2013 - Wiley Online Library
Malignant tumors remain a major health burden throughout the world and effective
therapeutic strategies are urgently needed. Cancer nanotechnology, as an integrated …

Engineered drug delivery nanosystems for tumor microenvironment normalization therapy

B Yang, F Meng, J Zhang, K Chen, S Meng, K Cai… - Nano Today, 2023 - Elsevier
As a complex" soil" ecosystem, the tumor microenvironment (TME) plays a crucial role in the
occurrence, development and metastasis of tumors. Reprogramming TME can block the …

Nanomedicine for tumor microenvironment modulation and cancer treatment enhancement

J Liu, Q Chen, L Feng, Z Liu - Nano Today, 2018 - Elsevier
Cancer, one of major threats to the human health, possesses intricate structure and
constituents distinctive from normal organs and tissues. It has been well recognized that the …

Nanoparticle-mediated targeted drug delivery to remodel tumor microenvironment for cancer therapy

L Tang, Y Mei, Y Shen, S He, Q Xiao, Y Yin… - International Journal …, 2021 - Taylor & Francis
Advanced research has revealed the crucial role of tumor microenvironment (TME) in
tumorigenesis. TME consists of a complicated network with a variety of cell types including …

[HTML][HTML] Tumor microenvironment and nanotherapeutics

M Upreti, A Jyoti, P Sethi - Translational cancer research, 2013 - ncbi.nlm.nih.gov
Recent studies delineate a predominant role for the tumor microenvironment in tumor growth
and progression. Improved knowledge of cancer biology and investigation of the complex …