Conflicting data exist on the role of nitric oxide (NO) in cerebral blood flow (CBF)
autoregulation. Previous studies involving human and animal subjects seem to indicate that …

Background—From animal studies it emerged that nitric oxide is important for the
modulation of CO2-mediated cerebral blood flow (CBF chemoregulation) but not for the …

The maintenance of constant cerebral blood flow (CBF) as arterial blood pressure is
reduced, commonly referred to as CBF-pressure autoregulation, is typically characterized by …

Key points• Arterial CO2 serves as a mediator of cerebral blood flow, and its relative
influence on the regulation of cerebral blood flow is defined as cerebral CO2 reactivity.• …

We studied the effect of nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase
(NOS) inhibitor, on the increases in cerebral blood flow (CBF) elicited by stepwise elevations …

Cerebral blood flow (CBF) is highly regulated by changes in arterial Pco2 and arterial Po2.
Evidence from animal studies indicates that various vasoactive factors, including release of …

Cerebral blood flow is highly sensitive to alterations in the partial pressures of O2 and CO2
(P and P, respectively) in the arterial blood. In humans, the extent to which nitric oxide (NO) …

Cerebrovascular CO2 reactivity (CVR) is often considered a bioassay of cerebrovascular
endothelial function. We recently introduced a test of cerebral shear‐mediated dilatation …

Non‐technical summary Two mechanisms control brain blood flow by changing blood
vessel diameter: autoregulation maintains flow in the face of perfusion pressure changes …

The importance of nitric oxide (NO) for CBF variations associated with arterial carbon
dioxide changes was investigated in halothane-anesthetized rats by using an inhibitor of …