Melanin is an Aspergillus flavus cell wall component that provides chemical and physical
protection to the organism. However, the molecular and biological mechanisms modulating …

Background Aspergillus fumigatus is the most common agent of invasive aspergillosis, a
feared complication in severely immunocompromised patients. Despite the recent …

In Aspergillus fumigatus, the conidial surface contains dihydroxynaphthalene (DHN)-
melanin. Six-clustered gene products have been identified that mediate sequential catalysis …

The pathogenic fungus Aspergillus fumigatus is able to adapt to extremely variable
environmental conditions. The A. fumigatus genome contains four genes coding for mitogen …

Many fungi produce melanins, which can play critical roles in virulence and pathogenicity. In
fungal pathogenic species, melanin confers protection against host immune defense …

The production of melanin significantly enhances the virulence of many important human
pathogenic fungi. Despite fungal melanin's importance in human disease, as well as …

Aspergillus fumigatus produces heavily melanized infectious conidia. The conidial melanin
is associated with fungal virulence and resistance to various environmental stresses. This 1 …

Melanin biopigments have been linked to fungal virulence. Aspergillus fumigatus conidia
are melanised and are weakly immunogenic. We show that melanin pigments on the surface …

Melanins are ubiquitous pigments found in all kingdoms of life. Most organisms use them for
protection from environmental stress, although some fungi employ melanins as virulence …

Aspergillus fumigatus is the most important air-borne fungal pathogen of humans. The
interaction of the pathogen with the host's immune system represents a key process to …