In multicellular organisms, all the cells are genetically identical but turn genes on or off at the
right time to promote differentiation into specific cell types. The regulation of higher-order …

One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

DNA methylation is a class of epigenetic modification essential for coordinating gene
expression timing and magnitude throughout normal brain development and for proper brain …

Epigenetics refers to a variety of processes that have heritable effects on gene expression
programs without changes in DNA sequence. Key players in epigenetic control are chemical …

DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

DNA methylation is a heritable and stable epigenetic mark associated with transcriptional
repression. Changes in the patterns and levels of global and regional DNA methylation …

Methylation of cytosines can mediate epigenetic gene silencing and is the only known DNA
modification in eukaryotes. Recent efforts to map DNA methylation across mammalian …

Over the last decade, an increasing number of reports underscored the importance of
epigenetic regulations in brain plasticity. Epigenetic elements such as readers, writers and …

Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

The addition of a methyl group to a DNA base is known as DNA methylation. Typically, this
occurs at the location of a cytosine proximal to a guanine base and is catalyzed by enzymes …