Electrophilic compounds are a newly recognized class of redox‐active neuroprotective
compounds with electron deficient, electrophilic carbon centers that react with specific …

In a previous study, we found that carnosic acid (CA) protected cortical neurons by activating
the Keap1/Nrf2 pathway, which activation was initiated by S-alkylation of the critical cysteine …

Ketone bodies (KB) have been shown to prevent neurodegeneration in models of
Parkinson's and Alzheimer's diseases, but the mechanisms underlying these effects remain …

Background Four-octyl itaconate (OI), the itaconate's cell-permeable derivative, can activate
Nrf2 signaling via alkylation of Keap1 at its cysteine residues. The current study tested the …

One hallmark of Alzheimer's disease is the accumulation of amyloid β-peptide (AP), which
can initiate a cascade of oxidative events that may result in neuronal death. Because …

Electrophilic neurite outgrowth-promoting prostaglandin (NEPP) compounds protect
neurons from oxidative insults. At least part of the neuroprotective action of NEPPs lies in …

Stroke is a complex disease involved oxidative stress-related pathways in its pathogenesis.
The nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway has …

To better understand the neurotrophic function of the neurotransmitter noradrenaline, we
have developed a model of mesencephalic cultures in which we find low concentrations (0.3 …

Living cells maintain a balance between oxidation and reduction, and perturbations of this
redox balance are thought to contribute to various diseases. Recent attemptsto regulate …

Living cells maintain a balance between oxidation and reduction, and perturbations of this
redox balance are thought to contribute to various diseases. Recent attempts to regulate …