[HTML][HTML] ENPP2 inhibitor improves proliferation in AOM/DSS-induced colorectal cancer mice via remodeling the gut barrier function and gut microbiota composition
J Yan, W Duan, Q Gao, T Mao, M Wang, J Duan… - Pharmacological …, 2023 - Elsevier
In our previous multicenter study, we delineated the inherent metabolic features of colorectal
cancer (CRC). Therein, we identified a member of the ectonucleotide pyrophosphatase …
cancer (CRC). Therein, we identified a member of the ectonucleotide pyrophosphatase …
[HTML][HTML] Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in ApcMin/+ mice
Studies showed that manipulation of gut microbiota (GM) composition through the treatment
of prebiotics could be a novel preventive measure against colorectal cancer (CRC) …
of prebiotics could be a novel preventive measure against colorectal cancer (CRC) …
[HTML][HTML] Theabrownin alleviates colorectal tumorigenesis in murine AOM/DSS model via PI3K/Akt/mTOR pathway suppression and gut microbiota modulation
Colorectal cancer (CRC) is one of the most common and fatal cancers worldwide, yet
therapeutic options for CRC often exhibit strong side effects which cause patients' well-being …
therapeutic options for CRC often exhibit strong side effects which cause patients' well-being …
[HTML][HTML] YYFZBJS inhibits colorectal tumorigenesis by remodeling gut microbiota and influence on M2 macrophage polarization in vivo and in vitro
N Chai, Y Xiong, Y Zhang, Y Cheng, W Shi… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Our previous studies indicated that the extract of Yi-Yi-Fu-Zi-Bai-Jiang-San (YYFZBJS) had
potent anticancer activities by significantly inhibiting intestinal tumor development in Apc …
potent anticancer activities by significantly inhibiting intestinal tumor development in Apc …
[HTML][HTML] Caffeic acid phenethyl ester prevents colitis-associated cancer by inhibiting NLRP3 inflammasome
G Dai, Z Jiang, B Sun, C Liu, Q Meng, K Ding… - Frontiers in …, 2020 - frontiersin.org
Long-lasting inflammation in the intestinal tract renders individuals susceptible to colitis-
associated cancer (CAC). The NOD-like receptor protein 3 (NLRP3) inflammasome plays a …
associated cancer (CAC). The NOD-like receptor protein 3 (NLRP3) inflammasome plays a …
Commensal microbiota-derived metabolite agmatine triggers inflammation to promote colorectal tumorigenesis
Y Lu, A Cui, X Zhang - Gut Microbes, 2024 - Taylor & Francis
Colorectal cancer (CRC), a malignant tumor worldwide, is associated with gut microbiota.
The influence of gut microbe-derived metabolites on CRC has attracted a lot of attention …
The influence of gut microbe-derived metabolites on CRC has attracted a lot of attention …
Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages via downregulating fatty acid oxidation to prevent colitis-associated cancer
S Qiao, C Lv, Y Tao, Y Miao, Y Zhu, W Zhang, D Sun… - Cancer Letters, 2020 - Elsevier
Arctigenin, the major active constituent of Fructus Arctii, has been reported to inhibit the
growth of various tumors and alleviate colitis. This study aimed to prove the protective effect …
growth of various tumors and alleviate colitis. This study aimed to prove the protective effect …
Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling
Nonsteroidal anti-inflammatory drugs (NSAID) display promising antineoplastic activity for
colorectal and other cancers, but toxicity from COX inhibition limits their long-term use for …
colorectal and other cancers, but toxicity from COX inhibition limits their long-term use for …
The COX-2–PGE2 Pathway Promotes Tumor Evasion in Colorectal Adenomas
J Wei, J Zhang, D Wang, B Cen, JD Lang… - Cancer Prevention …, 2022 - AACR
The mechanisms underlying the regulation of a checkpoint receptor, PD-1, in tumor-
infiltrating immune cells during the development of colorectal cancer are not fully …
infiltrating immune cells during the development of colorectal cancer are not fully …
[HTML][HTML] An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis
MC Lu, JA Ji, YL Jiang, ZY Chen, ZW Yuan, QD You… - Scientific Reports, 2016 - nature.com
Ulcerative colitis (UC) is a chronic relapsing-remitting form of inflammatory bowel disease
(IBD) that increases the risk of colorectal cancer, the third most common malignancy in …
(IBD) that increases the risk of colorectal cancer, the third most common malignancy in …