An EDS1-SAG101 Complex Is Essential for TNL-Mediated Immunity in Nicotiana benthamiana

J Gantner, J Ordon, C Kretschmer, R Guerois… - The Plant …, 2019 - academic.oup.com
Heterodimeric complexes containing the lipase-like protein ENHANCED DISEASE
SUSCEPTIBILITY1 (EDS1) are regarded as central regulators of plant innate immunity. In …

EDS1 complexes are not required for PRR responses and execute TNL‐ETI from the nucleus in Nicotiana benthamiana

J Zönnchen, J Gantner, D Lapin, K Barthel… - New …, 2022 - Wiley Online Library
Heterodimeric complexes incorporating the lipase‐like proteins EDS1 with PAD4 or SAG101
are central hubs in plant innate immunity. EDS1 functions encompass signal relay from TIR …

A coevolved EDS1-SAG101-NRG1 module mediates cell death signaling by TIR-domain immune receptors

D Lapin, V Kovacova, X Sun, JA Dongus… - The Plant …, 2019 - academic.oup.com
Plant nucleotide binding/leucine-rich repeat (NLR) immune receptors are activated by
pathogen effectors to trigger host defenses and cell death. Toll-interleukin 1 receptor domain …

[HTML][HTML] EDS1 signalling: At the nexus of intracellular and surface receptor immunity

JA Dongus, JE Parker - Current opinion in plant biology, 2021 - Elsevier
The conserved lipase-like protein EDS1 transduces signals from pathogen-activated
intracellular nucleotide-binding leucine-rich repeat (NLR) receptors to transcriptional …

Origins and immunity networking functions of EDS1 family proteins

D Lapin, DD Bhandari, JE Parker - Annual review of …, 2020 - annualreviews.org
The EDS1 family of structurally unique lipase-like proteins EDS1, SAG101, and PAD4
evolved in seed plants, on top of existing phytohormone and nucleotide-binding–leucine …

Different roles of Enhanced Disease Susceptibility1 (EDS1) bound to and dissociated from Phytoalexin Deficient4 (PAD4) in Arabidopsis immunity

S Rietz, A Stamm, S Malonek, S Wagner… - New …, 2011 - Wiley Online Library
Enhanced Disease Susceptibility1 (EDS1) is an important regulator of plant basal and
receptor‐triggered immunity. Arabidopsis EDS1 interacts with two related proteins …

Cavity surface residues of PAD4 and SAG101 contribute to EDS1 dimer signaling specificity in plant immunity

JA Dongus, DD Bhandari, E Penner, D Lapin… - The Plant …, 2022 - Wiley Online Library
Arabidopsis pathogen effector‐triggered immunity (ETI) is controlled by a family of three
lipase‐like proteins (EDS1, PAD4, and SAG101) and two subfamilies of HET‐S/LOB‐B …

Plant immunity: the EDS1 regulatory node

M Wiermer, BJ Feys, JE Parker - Current opinion in plant biology, 2005 - Elsevier
ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) and its interacting partner,
PHYTOALEXIN DEFICIENT 4 (PAD4), constitute a regulatory hub that is essential for basal …

Structural basis for signaling by exclusive EDS1 heteromeric complexes with SAG101 or PAD4 in plant innate immunity

S Wagner, J Stuttmann, S Rietz, R Guerois… - Cell host & …, 2013 - cell.com
Biotrophic plant pathogens encounter a postinfection basal resistance layer controlled by
the lipase-like protein enhanced disease susceptibility 1 (EDS1) and its sequence-related …

Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation

M Voss, C Toelzer, DD Bhandari, JE Parker… - Journal of structural …, 2019 - Elsevier
In plant innate immunity, enhanced disease susceptibility 1 (EDS1) integrates all pathogen-
induced signals transmitted by TIR-type NLR receptors. Driven by an N-terminal α/β …