RNA technology has recently come to the forefront of innovative medicines and is being
explored for a wide range of therapies, including prophylactic and therapeutic vaccines …

Therapeutic cancer vaccines, designed to activate immune effectors against tumor antigens,
utilize a number of different platforms for antigen delivery. Among these are messenger …

The development and success of RNA-based vaccines targeting SARS-CoV-2 has
awakened new interest in utilizing RNA vaccines against cancer, particularly in the …

Alphaviruses, flaviviruses, measles viruses and rhabdoviruses are enveloped single-
stranded RNA viruses, which have been engineered for recombinant protein expression and …

Self-replicating RNA viruses have been engineered as efficient expression vectors for
vaccine development for infectious diseases and cancers. Moreover, self-replicating RNA …

Historically poor clinical results of tumor vaccines have been attributed to weakly
immunogenic antigen targets, limited specificity, and vaccine platforms that fail to induce …

Self-replicating single-stranded RNA viruses such as alphaviruses, flaviviruses, measles
viruses, and rhabdoviruses provide efficient delivery and high-level expression of …

The advent of reverse genetic approaches to manipulate the genomes of both positive (+)
and negative (−) sense RNA viruses allowed researchers to harness these genomes for …

Recombinant nucleic acids are considered as promising next-generation vaccines. These
vaccines express the native antigen upon delivery into tissue, thus mimicking live attenuated …

Vaccinology is shifting toward synthetic RNA platforms which allow for rapid, scalable, and
cell-free manufacturing of prophylactic and therapeutic vaccines. The simple development …