[HTML][HTML] Tumor necrosis factor (TNF)-α-stimulated gene 6 (TSG-6): A promising immunomodulatory target in acute neurodegenerative diseases

D La Russa, C Di Santo, I Lizasoain, A Moraga… - International Journal of …, 2023 - mdpi.com
Tumor necrosis factor (TNF)-α-stimulated gene 6 (TSG-6), the first soluble chemokine-
binding protein to be identified in mammals, inhibits chemotaxis and transendothelial …

[HTML][HTML] Characterization of the Involvement of Tumour Necrosis Factor (TNF)-α-Stimulated Gene 6 (TSG-6) in Ischemic Brain Injury Caused by Middle Cerebral Artery …

C Di Santo, D La Russa, R Greco, A Persico… - International Journal of …, 2023 - mdpi.com
The identification of novel targets to modulate the immune response triggered by cerebral
ischemia is crucial to promote the development of effective stroke therapeutics. Since tumour …

[HTML][HTML] The anti-inflammatory protein TSG-6 regulates chemokine function by inhibiting chemokine/glycosaminoglycan interactions

DP Dyer, CL Salanga, SC Johns, E Valdambrini… - Journal of Biological …, 2016 - ASBMB
TNF-stimulated gene-6 (TSG-6) is a multifunctional protein secreted in response to pro-
inflammatory stimuli by a wide range of cells, including neutrophils, monocytes, and …

[HTML][HTML] An update on the role of tumor necrosis factor alpha stimulating gene-6 in inflammatory diseases

R Li, C Ji, M Dai, J Huang, W Xu, H Zhang, Y Ma - Molecular Immunology, 2022 - Elsevier
At present, the occurrence and development of inflammatory diseases are closely related to
the abnormal changes of the content and function of many cytokines. At the same time …

TSG-6: A multifunctional protein with anti-inflammatory and tissue-protective properties

AJ Day, CM Milner - Matrix Biology, 2019 - Elsevier
Tumor necrosis factor-(TNF) stimulated gene-6 (TSG-6) is an inflammation-associated
secreted protein that has been implicated as having important and diverse tissue protective …

[HTML][HTML] Tumor necrosis factor-inducible gene 6 protein: A novel neuroprotective factor against inflammation-induced developmental brain injury

F Bertling, I Bendix, K Drommelschmidt… - Experimental …, 2016 - Elsevier
Inflammation is an important factor contributing to developmental brain injury in preterm
infants. Although tumor necrosis factor-inducible gene 6 protein (TSG-6) has …

TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8

DP Dyer, JM Thomson, A Hermant… - The Journal of …, 2014 - journals.aai.org
Abstract TNF-stimulated gene/protein-6 (TSG-6) is expressed by many different cell types in
response to proinflammatory cytokines and plays an important role in the protection of …

TNF-stimulated gene-6 is a key regulator in switching stemness and biological properties of mesenchymal stem cells

B Romano, S Elangovan, M Erreni, E Sala, L Petti… - Stem Cells, 2019 - academic.oup.com
Mesenchymal stem cells (MSCs) are well established to have promising therapeutic
properties. TNF-stimulated gene-6 (TSG-6), a potent tissue-protective and anti-inflammatory …

[HTML][HTML] Modulation of Neuroinflammation: Advances in Roles and Mechanisms of the IL-33/ST2 Axis Involved in Ischemic Stroke

S Guo, C Qian, W Li, Z Zeng, J Cai, Y Luo - Neuroimmunomodulation, 2023 - karger.com
Abstract Interleukin (IL)-33 was initially recognized as a constituent of the IL-1 cytokine
family in 2005. It exerts pleiotropic effects by regulating immune responses via its binding to …

[HTML][HTML] Tumor necrosis factor-stimulated gene-6 (TSG-6) is constitutively expressed in adult central nervous system (CNS) and associated with astrocyte-mediated …

VJ Coulson-Thomas, ME Lauer, S Soleman… - Journal of Biological …, 2016 - ASBMB
Tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6) binds to hyaluronan and can
reorganize/stabilize its structure, also enhancing the binding of this glycosaminoglycan to its …