Renal nitrogen metabolism primarily involves urea and ammonia metabolism, and is
essential to normal health. Urea is the largest circulating pool of nitrogen, excluding nitrogen …

Renal ammonia metabolism and transport mediates a central role in acid-base homeostasis.
In contrast to most renal solutes, the majority of renal ammonia excretion derives from …

Acid-base homeostasis is critical to maintenance of normal health. Renal ammonia
excretion is the quantitatively predominant component of renal net acid excretion, both …

Acid-base homeostasis to a great extent relies on renal ammonia metabolism. In the past
several years, seminal studies have generated important new insights into the mechanisms …

The pathways responsible for an the mechanisms underlying the adaptive increase in
ammonia production in response to acidosis are considered. It seems unlikely that the …

The renal production of ammonia is classically perceived as a regulatory system which
responds to perturbations in the acid-base status of the organism [1–4]. A growing body of …

Ammonia, an important urinary buffer in mammals, is synthesized primarily in the proximal
tubules and is transferred to the final urine by a sequence of specialized transport …

Urea degradation was measured during 16 experiments in 13 chronic uremic patients being
treated with essential amino acids or their analogues.[14C] Urea was injected iv and the …

Urea is the chief end product of nitrogen metabolism in mammals. Most of the urea produced
is excreted by the kidneys. Excretion of a large fraction of the urea filtered by the glomerulus …

Chronic metabolic acidosis induces dramatic increases in net acid excretion that are
predominantly due to increases in urinary ammonia excretion. The current study examines …