Impaired cholesterol metabolism has been reported in Alzheimer's disease. Since ABCA1 is
one of the main players in the brain's cholesterol homeostasis, here we used the in-vitro and …

ATP-binding cassette transporter A7 (ABCA7) is expressed in the hippocampus and cortex
of the brain and was confirmed to be involved in the development of Alzheimer's disease …

ABCA1 promotes cholesterol efflux from cells and is required for maintaining plasma
cholesterol levels. Cholesterol homeostasis is important in the production of β‐amyloid (Aβ) …

Introduction Cholesterol homeostasis is critical for normal brain function. It is tightly
controlled by various biological elements. ATP-binding cassette transporter A1 (ABCA1) is a …

The role of ABCA7 in brain homeostasis and Alzheimer's disease (AD) is currently under
intense scrutiny, since it has been reported that polymorphisms in the Abca7 gene and a …

Brain cholesterol homeostasis is regulated by a group of proteins called ATP-binding
cassette subfamily A (ABCA) transporters. Certain ABCA transporters regulate amyloid-β …

We investigated the expression and function of Abca1 in wild-type C57BL/6, abca1 (+/+),
and abca1 (−/−) mice brain capillaries forming the blood–brain barrier (BBB). We first …

ABCA1, a cholesterol transporter expressed in the brain, has been shown recently to be
required to maintain normal apoE levels and lipidation in the central nervous system. In …

ATP-binding cassette transporter A1 (ABCA1) is a cholesterol transporter that transfers
excess cellular cholesterol onto lipid-poor apolipoproteins. Given its critical role in …

ABCA1-deficient mice have low levels of poorly lipidated apolipoprotein E (apoE) and
exhibit increased amyloid load. To test whether excess ABCA1 protects from amyloid …