[HTML][HTML] CK2 in cancer: cellular and biochemical mechanisms and potential therapeutic target

MMJ Chua, CE Ortega, A Sheikh, M Lee… - Pharmaceuticals, 2017 - mdpi.com
CK2 genes are overexpressed in many human cancers, and most often overexpression is
associated with worse prognosis. Site-specific expression in mice leads to cancer …

Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2

JS Duncan, DW Litchfield - Biochimica et Biophysica Acta (BBA)-Proteins …, 2008 - Elsevier
CK2 is a highly conserved protein serine/threonine kinase that is ubiquitously distributed in
eukaryotes, constitutively active and has been implicated in multiple cellular functions, as …

[HTML][HTML] Targeting CK2 in cancer: a valuable strategy or a waste of time?

M Salvi, C Borgo, LA Pinna, M Ruzzene - Cell death discovery, 2021 - nature.com
CK2 is a protein kinase involved in several human diseases (ranging from neurological and
cardiovascular diseases to autoimmune disorders, diabetes, and infections, including …

Development and exploitation of CK2 inhibitors

S Sarno, M Ruzzene, P Frascella, MA Pagano… - Molecular and cellular …, 2005 - Springer
A number of quite specific and fairly potent inhibitors of protein kinase CK2, belonging to the
classes of condensed polyphenolic compounds, tetrabromobenzimidazole/triazole …

[HTML][HTML] The CK1 family: contribution to cellular stress response and its role in carcinogenesis

U Knippschild, M Krüger, J Richter, P Xu… - Frontiers in …, 2014 - frontiersin.org
Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …

Emergence of protein kinase CK2 as a key target in cancer therapy

JH Trembley, Z Chen, G Unger, J Slaton, BT Kren… - Biofactors, 2010 - Wiley Online Library
Protein kinase CK2, a protein serine/threonine kinase, plays a global role in activities related
to cell growth, cell death, and cell survival. CK2 has a large number of potential substrates …

Protein kinase CK2 in health and disease: CK2: a key player in cancer biology

JH Trembley, G Wang, G Unger, J Slaton… - Cellular and molecular …, 2009 - Springer
Elevated levels of protein kinase CK2 (formerly casein kinase 2 or II) have long been
associated with increased cell growth and proliferation both in normal and cancer cells. The …

[HTML][HTML] Therapeutic targeting of CK2 in acute and chronic leukemias

F Buontempo, JA McCubrey, E Orsini, M Ruzzene… - Leukemia, 2018 - nature.com
CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is
considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy …

Protein kinase CK2 as regulator of cell survival: implications for cancer therapy

GM Unger, AT Davis, JW Slaton… - Current cancer drug …, 2004 - ingentaconnect.com
Recent studies have generated sufficient information to warrant a consideration of protein
kinase CK2 as a potential target for cancer therapy. CK2 is a ubiquitous and highly …

[HTML][HTML] Protein kinase CK2–diverse roles in cancer cell biology and therapeutic promise

JH Trembley, BT Kren, M Afzal, GA Scaria… - Molecular and cellular …, 2023 - Springer
The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …