The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

Y Zhang, Z Zhang - Cellular & molecular immunology, 2020 - nature.com
Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor
immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and …

Cancer immunotherapies: advances and bottlenecks

R Rui, L Zhou, S He - Frontiers in Immunology, 2023 - frontiersin.org
Immunotherapy has ushered in a new era in cancer treatment, and cancer immunotherapy
continues to be rejuvenated. The clinical goal of cancer immunotherapy is to prime host …

Immunosuppressive tumor microenvironment modulation by chemotherapies and targeted therapies to enhance immunotherapy effectiveness

R Barnestein, L Galland, L Kalfeist, F Ghiringhelli… - …, 2022 - Taylor & Francis
With the rapid clinical development of immune checkpoint inhibitors (ICIs), the standard of
care in cancer management has evolved rapidly. However, immunotherapy is not currently …

Targeted anti‐tumor immunotherapy using tumor infiltrating cells

Y Xie, F Xie, L Zhang, X Zhou, J Huang… - Advanced …, 2021 - Wiley Online Library
In the tumor microenvironment, T cells, B cells, and many other cells play important and
distinct roles in anti‐tumor immunotherapy. Although the immune checkpoint blockade and …

Modulation of the immune microenvironment by tumor-intrinsic oncogenic signaling

KB Nguyen, S Spranger - Journal of Cell Biology, 2019 - rupress.org
The development of cancer immunotherapies has been guided by advances in our
understanding of the dynamics between tumor cells and immune populations. An emerging …

The influence of microenvironment on tumor immunotherapy

J Zhang, Z Shi, X Xu, Z Yu, J Mi - The FEBS journal, 2019 - Wiley Online Library
Tumor immunotherapy has achieved remarkable efficacy, with immune‐checkpoint
inhibitors as especially promising candidates for cancer therapy. However, some issues …

Immuno-oncology-101: overview of major concepts and translational perspectives

B Allard, S Aspeslagh, S Garaud, FA Dupont… - Seminars in cancer …, 2018 - Elsevier
Cancer immunotherapy is demonstrating impressive clinical benefit in different malignancies
and clinical oncologists are increasingly turning their attention to immune-oncology. It is now …

Recent advances and challenges in cancer immunotherapy

C Peterson, N Denlinger, Y Yang - Cancers, 2022 - mdpi.com
Simple Summary Immunotherapy helps a person's immune system to target tumor cells.
Recent advances in cancer immunotherapy, including immune checkpoint inhibition …

Immune suppressive mechanisms in the tumor microenvironment

DH Munn, V Bronte - Current opinion in immunology, 2016 - Elsevier
Highlights•Tumors exaggerate and exploit natural immunosuppressive and tolerogenic
mechanisms.•This milieu favors angiogenesis and tissue remodeling but is suppressive for T …

The immune landscape of human tumors: Implications for cancer immunotherapy

G Bindea, B Mlecnik, HK Angell, J Galon - Oncoimmunology, 2014 - Taylor & Francis
Understanding the spontaneous immune response of cancer patients is critical for the
design of efficient anticancer immunotherapies. The power of integrative tumor immunology …