Mammalian embryos have evolved to adjust their organ and tissue development in
response to an atypical environment. This adaptation, called phenotypic plasticity, allows the …

Worldwide obesity is increasing at an alarming rate in children and adolescents, with the
consequent emergence of co-morbidities. Moreover, the maternal environment during …

Based on the concept of Developmental Origin of Health and Disease, both human and
animal studies have demonstrated a close link between nutrient supply perturbations in the …

Pregnancy is a physiological stress that requires dynamic, regulated changes affecting
maternal and fetal adiposity. Excessive accumulation of dysfunctional adipose tissue …

The primary markers of the metabolic syndrome are central obesity, insulin resistance and
hypertension. In this review, we consider the effect of changes in maternal nutrition during …

Abstract According to the Developmental Origin of Health and Disease (DOHaD) concept,
alterations of nutrient supply in the fetus or neonate result in long-term programming of …

Over recent decades there has been a rapid rise in metabolic disorders throughout the
world. Whilst lifestyle and societal habits have contributed to the obesity epidemic, there is …

The consequences of excessive maternal weight and adiposity at conception for the
offspring are now well recognized. Maternal obesity increases the risk of overweight and …

There is now clear evidence from population-based and experimental animal studies that
maternal obesity and maternal overnutrition, particularly excessive intake of high-fat and …

As obesity reaches epidemic levels in the United States there is an urgent need to
understand the developmental pathways leading to this condition. Obesity increases the risk …