Decades of research have elucidated the critical role of Akt isoforms in cancer as pro-
tumorigenic and metastatic regulators through their specific effects on the cancer cells, tumor …

AKT is a central signaling molecule in regulating cell survival, proliferation, tumor growth
and angiogenesis. Upstream components of AKT signaling pathway such as PI3K, PTEN …

Akt (protein kinase B) is a serine/threonine kinase which is a central regulator of widely
divergent cellular processes including proliferation, differentiation, migration, survival and …

AKT is a serine/threonine kinase activated downstream of integrin, which is a receptor for
various pro‑proliferation and bioactive substances as well as the extracellular matrix …

The frequent deregulation of the phosphoinositide 3-kinase/Akt survival signaling pathway
in cancer has prompted significant interest in blocking this pathway to treat cancer. Recently …

The serine/threonine kinases, Akti/PKBα, Akt2/PKBβ, and Akt3/PKBγ, play a critical role in
preventing cancer cells from undergoing apoptosis. However, the function of individual Akt …

Akt kinase is a serine threonine kinase that exists in three isoforms, located in different
chromosomes and has distinct sites of expression which orchestrates diverse cellular …

Growth factor signaling plays a pivotal role in diverse biological functions, such as cell
growth, apoptosis, senescence, and migration and its deregulation has been linked to …

Akt/PKB kinases are central mediators of cell homeostasis. There are three highly
homologous Akt isoforms, Akt1/PKBα, Akt2/PKBβ and Akt3/PKBγ. Hyperactivation of Akt …

Akt serine/threonine kinases, or PKB, are key players in the regulation of a wide variety of
cellular activities, such as growth, proliferation, protection from apoptotic injuries, control of …