Autoimmune disorders, including rheumatoid arthritis, inflammatory bowel disease,
psoriasis, and others, are characterized by dysregulation of various aspects of normal …

Biologic agents have substantially advanced the treatment of immunological disorders,
including chronic inflammatory and autoimmune diseases. However, these drugs are often …

As the use of biological therapies expands, the number and diversity of induced
autoimmune disorders should be expected to increase. Paradoxically, for many of these …

Biological agents represent a major advance in the treatment of rheumatic diseases, most
particularly in the prevention of irreversible structural damage. While generally well …

Introduction: Biological drugs are therapies designed to target a specific molecule of the
immune system that have been linked with the development of autoimmune diseases. Areas …

Autoimmune diseases are a result of the immune system being misdirected toward its host
and have major and increasing unmet clinical needs. In general, present therapies are …

Autoimmunity occurs when T cells, B cells or both are inappropriately activated, resulting in
damage to one or more organ systems. Normally, high-affinity self-reactive T and B cells are …

Targeted immune-modulating treatment with biological agents has revolutionized the
management of immune-mediated inflammatory diseases, including rheumatologic …

Immunomodulatory biologics, which render their therapeutic effects by modulating or
harnessing immune responses, have proven their therapeutic utility in several complex …

Drug-induced autoimmunity is an idiosyncratic, non-IgE immune related drug reaction.
Interestingly, although many drugs have been reported to induce autoantibodies, only a few …