Enrollment of diverse populations in the INGENIOUS pharmacogenetics clinical trial

E Shah-Williams, KD Levy, Y Zang, AM Holmes… - Frontiers in …, 2020 - frontiersin.org
Recruitment of diverse populations and subjects living in Medically Underserved Areas and
Populations (MUA/P's) into clinical trials is a considerable challenge. Likewise …

Pharmacogenetic research in partnership with American Indian and Alaska Native communities

EL Woodahl, LJ Lesko, S Hopkins… - …, 2014 - Taylor & Francis
Pharmacogenetics is a subset of personalized medicine that applies knowledge about
genetic variation in gene–drug pairs to help guide optimal dosing. There is a lack of data …

Ensuring equity: Pharmacogenetic implementation in rural and tribal communities

TM Leitch, SR Killam, KE Brown… - Frontiers in …, 2022 - frontiersin.org
Implementation strategies for pharmacogenetic testing have been largely limited to major
academic medical centers and large health systems, threatening to exacerbate healthcare …

Implementation of a pharmacogenomics consult service to support the INGENIOUS trial

MT Eadon, Z Desta, KD Levy, BS Decker… - Clinical …, 2016 - Wiley Online Library
Hospital systems increasingly utilize pharmacogenomic testing to inform clinical prescribing.
Successful implementation efforts have been modeled at many academic centers. In …

Exploring perceptions, knowledge, and attitudes regarding pharmacogenetic testing in the medically underserved

BE Gawronski, EJ Cicali, CW McDonough… - Frontiers in …, 2023 - frontiersin.org
Introduction: Pharmacogenetic testing may hold promise in addressing health disparities, as
medically underserved patients appear to be prescribed medications with pharmacogenetic …

A review of African Americans' beliefs and attitudes about genomic studies: opportunities for message design

CL Scherr, S Ramesh, C Marshall-Fricker… - Frontiers in …, 2019 - frontiersin.org
Precision Medicine, the practice of targeting prevention and therapies according to an
individual's lifestyle, environment or genetics, holds promise to improve population health …

A qualitative study exploring barriers and facilitators of enrolling underrepresented populations in clinical trials and biobanking

TC Davis, CL Arnold, G Mills, L Miele - Frontiers in Cell and …, 2019 - frontiersin.org
Disparities exist in enrollment in clinical trials and biorepositories among adults with low
socioeconomic status, racial and ethnic minority groups and individuals who live in rural …

Ethical issues in developing pharmacogenetic research partnerships with American Indigenous communities

BB Boyer, D Dillard, EL Woodahl… - Clinical …, 2011 - Wiley Online Library
Pharmacogenetic research offers the potential to improve the safety and efficacy of drug
prescribing. Assuring that the benefits of this research reach indigenous and other medically …

Implementing pharmacogenetics in clinical trials: considerations about current methodological, ethical, and regulatory challenges

I Garcia-Garcia, E Seco-Meseguer… - Expert Review of …, 2024 - Taylor & Francis
Introduction The implementation of pharmacogenetic analysis within clinical trials faces
methodological, ethical, and regulatory challenges, as well as tackling the difficulty in …

Mapping Strategies for Reaching Socioeconomically Disadvantaged Populations in Clinical Trials

MI Florez, E Botto, JY Kim - JAMA Network Open, 2024 - jamanetwork.com
Importance Socioeconomically disadvantaged patients, such as persons with low income
and those with low educational attainment, are less likely to participate in clinical trials than …