Protein kinase C has a crucial role in signal transduction for a variety of biologically active
substances which activate cellular functions and proliferation. When cells are stimulated …

The activation of protein kinase C by diacylglycerol and by tumour promoters has implicated
this enzyme in transmembrane signalling and in the regulation of the cell cycle1, 2. In vitro …

It is now widely accepted that tumour-promoting phorbol esters activate a Ca2+-and
phospholipid-dependent protein kinase (protein kinase C) both in vitro and in intact cells1 …

Protein kinase C functions as the transducer of a second messenger, diacylglycerol, and is
the major receptor for tumour-promoting phorbol esters. The enzyme is a family of proteins …

Protein kinase C has now attracted great attention for the studies on the activation of cellular
functions and proliferation, and our knowledge of the possible role of this enzyme in cell …

A tumor-promoting phorbol ester,[3H] phorbol-12, 13-dibutyrate, may bind to a
homogeneous preparation of Ca2+-activated, phospholipid-dependent protein kinase …

The protein kinase C (PKC) family of enzymes has been the subject of a great deal of
research in the last few years because of the recognized importance of these enzymes in the …

Protein kinase C, an enzyme that is activated by diacylglycerol resulting from the receptor-
mediated hydrolysis of inositol phospholipids, relays information of a variety of extracellular …

The phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) is an efficient tumour
promoter in vivo. In vitro, TPA activates the phospholipid-and Ca2+-dependent protein …

EXPRESSION of normal protein kinase C (PKC) isoenzymes in fibroblasts has been shown
to alter growth regulation but has failed to induce complete transformation of the recipient …