Breath biopsy and discovery of exclusive volatile organic compounds for diagnosis of infectious diseases

JE Belizário, J Faintuch, MG Malpartida - Frontiers in cellular and …, 2021 - frontiersin.org
Exhaled breath contains thousand metabolites and volatile organic compounds (VOCs) that
originated from both respiratory tract and internal organ systems and their microbiomes …

Exhaled volatile organic compounds of infection: a systematic review

WM Ahmed, O Lawal, TM Nijsen… - ACS Infectious …, 2017 - ACS Publications
With heightened global concern of microbial drug resistance, advanced methods for early
and accurate diagnosis of infection are urgently needed. Analysis of exhaled breath volatile …

In vitro volatile organic compound profiling using GC× GC-TOFMS to differentiate bacteria associated with lung infections: a proof-of-concept study

KD Nizio, KA Perrault, AN Troobnikoff… - Journal of breath …, 2016 - iopscience.iop.org
Chronic pulmonary infections are the principal cause of morbidity and mortality in individuals
with cystic fibrosis (CF). Due to the polymicrobial nature of these infections, the identification …

[HTML][HTML] Modern approaches for detection of volatile organic compounds in metabolic studies focusing on pathogenic bacteria: current state of the art

K Żuchowska, W Filipiak - Journal of Pharmaceutical Analysis, 2023 - Elsevier
Pathogenic microorganisms produce numerous metabolites, including volatile organic
compounds (VOCs). Monitoring these metabolites in biological matrices (eg, urine, blood, or …

Detecting bacterial lung infections: in vivo evaluation of in vitro volatile fingerprints

J Zhu, HD Bean, MJ Wargo, LW Leclair… - Journal of breath …, 2013 - iopscience.iop.org
The identification of bacteria by their volatilomes is of interest to many scientists and
clinicians as it holds the promise of diagnosing infections in situ, particularly lung infections …

The versatile use of exhaled volatile organic compounds in human health and disease

AW Boots, JJBN van Berkel, JW Dallinga… - Journal of breath …, 2012 - iopscience.iop.org
Exhaled breath contains thousands of volatile organic compounds (VOCs) of which the
composition varies depending on health status. Various metabolic processes within the …

Clinical application of volatile organic compound analysis for detecting infectious diseases

S Sethi, R Nanda, T Chakraborty - Clinical microbiology reviews, 2013 - Am Soc Microbiol
This review article introduces the significance of testing of volatile organic compounds
(VOCs) in clinical samples and summarizes important features of some of the technologies …

Volatile metabolites of pathogens: a systematic review

LDJ Bos, PJ Sterk, MJ Schultz - PLoS pathogens, 2013 - journals.plos.org
Ideally, invading bacteria are detected as early as possible in critically ill patients: the strain
of morbific pathogens is identified rapidly, and antimicrobial sensitivity is known well before …

Microbial volatile compounds in health and disease conditions

RMS Thorn, J Greenman - Journal of Breath Research, 2012 - iopscience.iop.org
Microbial cultures and/or microbial associated diseases often have a characteristic smell.
Volatile organic compounds (VOCs) are produced by all microorganisms as part of their …

Analysis of biogenic volatile organic compounds in human health and disease

J Dummer, M Storer, M Swanney, M McEwan… - TrAC Trends in …, 2011 - Elsevier
The analysis of volatile biomarkers of disease in breath is attractive because breath analysis
is non-invasive and quick, and allows for repeated sampling. Challenges faced in the …