[图书][B] Cell and organoid models to develop new antivirals and diagnostic methods for emerging viruses

A Pettke - 2021 - search.proquest.com
The ongoing global pandemic of severe acute respiratory syndrome coronavirus 2
(SARSCoV-2) is only the latest reminder of the urgent need for new antiviral strategies and …

Host cell targets for unconventional antivirals against RNA viruses

VC Roa-Linares, M Escudero-Flórez… - Viruses, 2023 - mdpi.com
The recent COVID-19 crisis has highlighted the importance of RNA-based viruses. The most
prominent members of this group are SARS-CoV-2 (coronavirus), HIV (human …

[引用][C] Host cell targets for unconventional antivirals against RNA viruses. Viruses. 2023; 15: 776

VC Roa-Linares, M Escudero-Flórez… - 2023 - europepmc.org
The recent COVID-19 crisis has highlighted the importance of RNA-based viruses. The most
prominent members of this group are SARS-CoV-2 (coronavirus), HIV (human …

Proof-of-concept for effective antiviral activity of an in silico designed decoy synthetic mRNA against SARS-CoV-2 in the Vero E6 cell-based infection model

N Atari, O Erster, YH Shteinberg, H Asraf… - Frontiers in …, 2023 - frontiersin.org
The positive-sense single-stranded (ss) RNA viruses of the Betacoronavirus (beta-CoV)
genus can spillover from mammals to humans and are an ongoing threat to global health …

Review of studies of severe acute respiratory syndrome related coronavirus–2 pathogenesis in human organoid models

E Egilmezer, WD Rawlinson - Reviews in medical virology, 2021 - Wiley Online Library
Severe acute respiratory syndrome related coronavirus‐2 (SARS‐CoV‐2) is the cause of
Covid‐19 which was classified as a global pandemic in March 2020. The increasing global …

Predicting host-based, synthetic lethal antiviral targets from omics data

JP Staheli, ML Neal, A Navare, FD Mast… - NAR Molecular …, 2024 - academic.oup.com
Traditional antiviral therapies often have limited effectiveness due to toxicity and the
emergence of drug resistance. Host-based antivirals are an alternative, but can cause …

Targeting structured RNA in viruses

A Yu - 2023 - escholarship.org
Drug discovery in the last century has largely been dominated by therapeutics targeting
proteins. RNA targeting has remained largely elusive and high-risk, but some recent …

[HTML][HTML] Experimental models for SARS-CoV-2 infection

T Kim, JS Lee, YS Ju - Molecules and cells, 2021 - Elsevier
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is a novel virus that causes
coronavirus disease 2019 (COVID-19). To understand the identity, functional characteristics …

Organoid Models of SARS-CoV-2 infection: what have we learned about COVID-19?

BM Tran, G Deliyannis, A Hachani, L Earnest, J Torresi… - Organoids, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), which was classified as a pandemic in March 2020. As of 22 …

[HTML][HTML] Human organoids as a promising platform for fighting COVID-19

D Chen, X Su, H Chen, S Chen, Y Zhao… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Abstract The coronavirus disease 2019 (COVID-19) global pandemic evoked by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a major public health …