The increasing prevalence of food allergies has been linked to reduced commensal
microbial diversity. In this article, we describe two features of allergy-protective Clostridia …

Environmentally induced alterations in the commensal microbiota have been implicated in
the increasing prevalence of food allergy. We show here that sensitization to a food allergen …

Alterations in the gut microbiota composition are associated with food allergy. Toll-like
receptors (TLRs) respond to microbial stimuli. We studied the effects of the ligation of TLRs …

The mechanisms by which signaling by the innate immune system controls susceptibility to
allergy are poorly understood. In this report, we show that intragastric administration of a …

The prevalence of life-threatening anaphylactic responses to food is rising at an alarming
rate. The emerging role of the gut microbiota in regulating food allergen sensitization may …

Mucosal surfaces are in continuous contact with microbes. Toll-like receptors (TLRs)
mediate recognition of microbial molecules to eliminate pathogens. In contrast, we …

Flagellin, the protein subunit of the bacterial flagellum, stimulates the innate immune
receptor Toll-like receptor 5 (TLR5) after pattern recognition or evades TLR5 through lack of …

Innate lymphoid cells (ILCs) have emerged as important players, regulating the balance
between protective immunity and immunopathology at mucosal surfaces. However …

Highlights•The commensal microbiota regulates sensitization to food antigens.•Many cell
types interact with commensal bacteria including IEC, DC, and ILC.•Signaling by TLR or …

Highlights•Food allergy (FA) is characterized by pathogenic dysbiosis.•The dysbiosis in FA
disrupts oral tolerance to dietary antigens by impairing the generation of ROR-γt+ induced …