Pf bacteriophage are temperate phages that infect the bacterium Pseudomonas aeruginosa,
a major cause of chronic lung infections in cystic fibrosis (CF) and other settings. Pf and …

Pseudomonas aeruginosa is an important opportunistic human pathogen that lives in biofilm-
like cell aggregates at sites of chronic infection, such as those that occur in the lungs of …

Filamentous bacteriophage (Pf phage) contribute to the virulence of Pseudomonas
aeruginosa infections in animal models, but their relevance to human disease is unclear. We …

Background Pseudomonas aeruginosa causes lung infections in patients suffering from the
genetic disorder Cystic Fibrosis (CF). Once a chronic lung infection is established, P …

INTRODUCTION We have identified previously unsuspected, directly pathogenic roles for
bacteriophage (phage) virions in bacterial infections. In particular, we report that …

Bacteriophages (phages) are the most abundant biological entity in the human body, but
until recently the role that phages play in human health was not well characterized. Although …

Pseudomonas aeruginosa is an opportunistic pathogen that causes infections in a variety of
settings. Many P. aeruginosa isolates are infected by filamentous Pf bacteriophage …

Mature Pseudomonas aeruginosa biofilms undergo specific developmental events. Using a
bacteriophage mutant, generated by deletion of the entire filamentous Pf4 prophage, we …

For decades, a wealth of information has been acquired to define how host associated
microbial communities contribute to health and disease. Within the human microbiota this …

Temperate phages drive genomic diversification in bacterial pathogens. Phage-derived
sequences are more common in pathogenic than nonpathogenic taxa and are associated …