Deregulation of normal regenerative responses to physical, chemical and biological toxins
in susceptible individuals leads to abnormal remodelling of extracellular matrix with …

Radiation fibrosis is a frequent sequel of therapeutic or accidental radiation overexposure in
normal human tissues. One of the main fundamental problems yet unsolved in fibrotic …

Cancer survivors previously treated with curative radiotherapy are at risk of developing long-
term toxicities due to radiation-induced normal tissue injury. Radiation fibrosis is an …

Radiotherapy is a major cancer treatment option but dose-limiting side effects such as late-
onset fibrosis in the irradiated tissue severely impair quality of life in cancer survivors. Efforts …

Fibrosis is a common sequela of both cancer treatment by radiotherapy and accidental
irradiation and has been described in many tissues including skin, lung, heart and liver. The …

Cancer remains the leading cause of death around the world. In cancer treatment, over 50%
of cancer patients receive radiotherapy alone or in multimodal combinations with other …

A workshop entitled “Radiation-Induced Fibrosis: Mechanisms and Opportunities to
Mitigate”(held in Rockville, MD, September 19, 2016) was organized by the Radiation …

The radiation-induced fibroatrophic process (RIF) constitutes a late, local and unavoidable
sequela to high-dose radiotherapy, traditionally considered irreversible. Today, this process …

Radiation-induced fibrosis (RIF) represents one of the most common long-term adverse
effects of curative radiotherapy. Current cancer treatment approaches, involving more …

Purpose Radiation-induced fibrosis (RIF) is a long-term side effect of external beam
radiation therapy for the treatment of cancer. It results in a multitude of symptoms that …