[图书][B] Targeting the Aspergillus fumigatus Cell Wall with Polysaccharide-Specific Proteins

B Snarr - 2019 - search.proquest.com
Aspergillus fumigatus is a ubiquitous mould that can cause life-threatening pneumonia in
immunocompromised patients. A primary component contributing to the virulence of A …

Molecular mechanism of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases

F Le Mauff, NC Bamford, N Alnabelseya… - Journal of Biological …, 2019 - ASBMB
During infection, the fungal pathogen Aspergillus fumigatus forms biofilms that enhance its
resistance to antimicrobials and host defenses. An integral component of the biofilm matrix is …

Galectin-3 enhances neutrophil motility and extravasation into the airways during Aspergillus fumigatus infection

BD Snarr, G St-Pierre, B Ralph, M Lehoux… - PLoS …, 2020 - journals.plos.org
Aspergillus fumigatus is an opportunistic mold that infects patients who are
immunocompromised or have chronic lung disease, causing significant morbidity and …

The role of Aspergillus fumigatus polysaccharides in host–pathogen interactions

CA Zacharias, DC Sheppard - Current opinion in microbiology, 2019 - Elsevier
Aspergillus fumigatus is a saprophytic mold that can cause infection in patients with
impaired immunity or chronic lung diseases. The polysaccharide-rich cell wall of this fungus …

[图书][B] The Synthesis and Functions of Galactosaminogalactan in Aspergillus Species

MJ Lee - 2014 - search.proquest.com
Invasive pulmonary aspergillosis (IA) is a progressive necrotizing pneumonia that affects
immunosuppressed patients. The most frequently recovered isolate in patients with IA is …

Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity

BD Snarr, P Baker, NC Bamford… - Proceedings of the …, 2017 - National Acad Sciences
Galactosaminogalactan and Pel are cationic heteropolysaccharides produced by the
opportunistic pathogens Aspergillus fumigatus and Pseudomonas aeruginosa, respectively …

Aspergillus Galactosaminogalactan Mediates Adherence to Host Constituents and Conceals Hyphal β-Glucan from the Immune System

FN Gravelat, A Beauvais, H Liu, MJ Lee… - PLoS …, 2013 - journals.plos.org
Aspergillus fumigatus is the most common cause of invasive mold disease in humans. The
mechanisms underlying the adherence of this mold to host cells and macromolecules have …

Galectin-3 induces death of Candida species expressing specific β-1, 2-linked mannans

L Kohatsu, DK Hsu, AG Jegalian, FT Liu… - The Journal of …, 2006 - journals.aai.org
Lectins play a critical role in host protection against infection. The galectin family of lectins
recognizes saccharide ligands on a variety of microbial pathogens, including viruses …

Fungal polysaccharides promote protective immunity

GH Goldman, Y Delneste, N Papon - Trends in Microbiology, 2021 - cell.com
Fungal pathogens represent a rising threat against immunocompromised patients. By using
Aspergillus fumigatus, Briard et al. showed that the cell wall galactosaminogalactan (GAG) …

Preclinical evaluation of recombinant microbial glycoside hydrolases in the prevention of experimental invasive aspergillosis

H Ostapska, D Raju, M Lehoux, I Lacdao, S Gilbert… - Mbio, 2021 - Am Soc Microbiol
Aspergillus fumigatus is a ubiquitous mold that can cause invasive pulmonary infections in
immunocompromised patients. Within the lung, A. fumigatus forms biofilms that can enhance …