Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats

H Nishimura, M Yoshimura, M Shimizu… - Communications …, 2022 - nature.com
Oxytocin is involved in pain transmission, although the detailed mechanism is not fully
understood. Here, we generate a transgenic rat line that expresses human muscarinic …

Oxytocin and pain perception: from animal models to human research

S Boll, ACA De Minas, A Raftogianni, SC Herpertz… - Neuroscience, 2018 - Elsevier
An accumulating body of evidence suggests that the hypothalamic neuropeptide oxytocin
(OT) has a modulatory effect on pain processing. Particularly strong evidence comes from …

Oxytocin mediates stress‐induced analgesia in adult mice

DA Robinson, F Wei, GD Wang, P Li… - The Journal of …, 2002 - Wiley Online Library
As a neurohormone and as a neurotransmitter, oxytocin has been implicated in the stress
response. Descending oxytocin‐containing fibres project to the dorsal horn of the spinal …

Central administration of oxytocin reduces hyperalgesia in mice: implication for cannabinoid and opioid systems

R Russo, G D'Agostino, GM Raso, C Avagliano… - Peptides, 2012 - Elsevier
The neuropeptide oxytocin (OXT) contributes to the regulation of diverse cognitive and
physiological functions including nociception. Indeed, OXT has been reported to be …

Oxytocin: crossing the bridge between basic science and pharmacotherapy

C Viero, I Shibuya, N Kitamura… - CNS neuroscience & …, 2010 - Wiley Online Library
Is oxytocin the hormone of happiness? Probably not. However, this small nine amino acid
peptide is involved in a wide variety of physiological and pathological functions such as …

The analgesic effects of oxytocin in the peripheral and central nervous system

Q Xin, B Bai, W Liu - Neurochemistry International, 2017 - Elsevier
Pain is a ubiquitously unpleasant feeling among humans as well as many animal species
often caused by actual and potential tissue damage. However, it is absolutely crucial for our …

Oxytocin: pain relief in skin

V Grinevich, A Charlet - Pain, 2017 - journals.lww.com
The hypothalamic neuropeptide oxytocin attracts the attention of both the neuroscientific
community and the general public, especially because of its prosocial effects. In the brain …

Neuropathic pain up-regulates hypothalamo-neurohypophysial and hypothalamo-spinal oxytocinergic pathways in oxytocin-monomeric red fluorescent protein 1 …

H Nishimura, M Kawasaki, H Suzuki, T Matsuura… - Neuroscience, 2019 - Elsevier
Despite the high incidence of neuropathic pain, its mechanism remains unclear. Oxytocin
(OXT) is an established endogenous polypeptide produced in the supraoptic nucleus (SON) …

[HTML][HTML] Sex and hormonal status influence the anxiolytic-like effect of oxytocin in mice

KE Nisbett, LA Gonzalez, M Teruel, CS Carter… - Neurobiology of …, 2023 - Elsevier
Anxiety and depression are highly prevalent psychiatric disorders, affecting approximately
18% of the United States population. Evidence indicates that central oxytocin mediates …

The antinociception of oxytocin on colonic hypersensitivity in rats was mediated by inhibition of mast cell degranulation via Ca2+-NOS pathway

L Gong, J Li, Y Tang, T Han, C Wei, X Yu, J Li… - Scientific Reports, 2016 - nature.com
This study was conducted to investigate the effects of oxytocin (OT) on visceral
hypersensitivity/pain and mast cell degranulation and the underlying mechanisms. We found …