Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Posttranslational modification

VN Uversky - 2013 - digitalcommons.usf.edu
At the later stages of protein biosynthesis, after their transcription, many proteins undergo
intensive chemical alterations, collectively known as protein posttranslational modifications …

Small changes huge impact: the role of protein posttranslational modifications in cellular homeostasis and disease

TM Karve, AK Cheema - Journal of amino acids, 2011 - Wiley Online Library
Posttranslational modifications (PTMs) modulate protein function in most eukaryotes and
have a ubiquitous role in diverse range of cellular functions. Identification, characterization …

Role of posttranslational modifications of proteins in cardiovascular disease

YP Liu, TN Zhang, R Wen, CF Liu… - Oxidative Medicine and …, 2022 - Wiley Online Library
Cardiovascular disease (CVD) has become a leading cause of mortality and morbidity
globally, making it an urgent concern. Although some studies have been performed on CVD …

[图书][B] Post-translational modifications in health and disease

CJ Vidal - 2010 - books.google.com
Post-translational modifications serve many different purposes in several cellular processes
such as gene expression, protein folding and transport to appropriate cell compartment …

[HTML][HTML] Roles of protein post-translational modifications in glucose and lipid metabolism: mechanisms and perspectives

YH Yang, R Wen, N Yang, TN Zhang, CF Liu - Molecular medicine, 2023 - Springer
The metabolism of glucose and lipids is essential for energy production in the body, and
dysregulation of the metabolic pathways of these molecules is implicated in various acute …

[图书][B] Post-Translational Modif ications of Proteins

C Kannicht, B Fuchs - 2008 - Springer
Post-translational modifications (PTMs) of proteins are referred to as chemical modifications
or cleavage of the protein after its translation. The protein's polypeptide chain may be altered …

Proteomic characterization of post-translational modifications in drug discovery

L Zhai, K Chen, B Hao, M Tan - Acta Pharmacologica Sinica, 2022 - nature.com
Protein post-translational modifications (PTMs), which are usually enzymatically catalyzed,
are major regulators of protein activity and involved in almost all celluar processes …

[HTML][HTML] Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies

X Wu, M Xu, M Geng, S Chen, PJ Little, S Xu… - Signal transduction and …, 2023 - nature.com
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Proteomic databases and tools to decipher post-translational modifications

KS Kamath, MS Vasavada, S Srivastava - Journal of proteomics, 2011 - Elsevier
Post-translational modifications (PTMs) are vital cellular control mechanism, which affect
protein properties, including folding, conformation, activity and consequently, their functions …