Tissue transglutaminase: A multifunctional and multisite regulator in health and disease

Z Yao, Y Fan, L Lin, RE Kellems… - Physiological …, 2024 - journals.physiology.org
Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

Cellular functions of tissue transglutaminase

MV Nurminskaya, AM Belkin - International review of cell and molecular …, 2012 - Elsevier
Transglutaminase 2 (TG2 or tissue transglutaminase) is a highly complex multifunctional
protein that acts as transglutaminase, GTPase/ATPase, protein disulfide isomerase, and …

Transglutaminase 2: a multi-functional protein in multiple subcellular compartments

D Park, SS Choi, KS Ha - Amino acids, 2010 - Springer
Abstract Transglutaminase 2 (TG2) is a multifunctional protein that can function as a
transglutaminase, G protein, kinase, protein disulfide isomerase, and as an adaptor protein …

[HTML][HTML] Transglutaminase 2: a molecular Swiss army knife

S Gundemir, G Colak, J Tucholski… - Biochimica et Biophysica …, 2012 - Elsevier
Transglutaminase 2 (TG2) is the most widely distributed member of the transglutaminase
family with almost all cell types in the body expressing TG2 to varying extents. In addition to …

Transglutaminase regulation of cell function

RL Eckert, MT Kaartinen, M Nurminskaya… - Physiological …, 2014 - journals.physiology.org
Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding
functions that participate in regulation of cell fate in a wide range of cellular systems and are …

Role of transglutaminase 2 in cell death, survival, and fibrosis

H Tatsukawa, K Hitomi - Cells, 2021 - mdpi.com
Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme catalyzing the crosslinking
between Gln and Lys residues and involved in various pathophysiological events. Besides …

Extracellular TG2: emerging functions and regulation

AM Belkin - The FEBS journal, 2011 - Wiley Online Library
Tissue transglutaminase (TG2) is a ubiquitously expressed member of the transglutaminase
family of Ca2+‐dependent crosslinking enzymes. Unlike other family members, TG2 is a …

Human tissue transglutaminase is inhibited by pharmacologic and chemical acetylation

TS Lai, C Davies, CS Greenberg - Protein Science, 2010 - Wiley Online Library
Human tissue transglutaminase (TGM2) is implicated in the pathogenesis of several
neurodegenerative disorders including Alzheimer's, Parkinson's and expanded …

Structural aspects of transglutaminase 2: functional, structural, and regulatory diversity

CS Lee, HH Park - Apoptosis, 2017 - Springer
Abstract Transglutaminase 2 (TG2) is a multi-functional protein that has both protein cross-
linking and guanosine 5′-triphosphate (GTP) hydrolysis activities. The activities of this …

Tissue transglutaminase and the stress response

R Ientile, D Caccamo, M Griffin - Amino acids, 2007 - Springer
The expression of the protein crosslinking enzyme tissue transglutaminase (TG2, tTG), the
ubiquitous member of transglutaminase family, can be regulated by multiple factors …