Within the pancreatic islet, the β-cell represents the ultimate biosensor. Its central function is
to accurately sense glucose levels in the blood and consequently release appropriate …

The intra-islet microvasculature is a critical interface between the blood and islet endocrine
cells governing a number of cellular and pathophysiological processes associated with the …

The pancreatic islet is highly vascularised, with an extensive capillary network. In addition to
providing nutrients and oxygen to islet endocrine cells and transporting hormones to the …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

The regulation of insulin secretion is under control of a complex inter-organ/cells crosstalk
involving various metabolites and/or physical connections. In this review, we try to illustrate …

The islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and
are complex microorgans embedded within the larger volume of the exocrine pancreas …

Pancreatic islets are clusters of hormone-secreting endocrine cells that rely on intricate cell-
cell communication mechanisms for proper function. The importance of multicellular …

Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While
long known, recent technological advances and new markers have allowed the identification …

The β-cells of the islets of Langerhans are embedded in a dense capillary network. The
blood vessels supply the islet cells with nutrients and oxygen, and in turn take up the …

Diabetes, particularly type 1 diabetes, results from the lack of pancreatic β-cells. β-cell
replenishment can functionally reverse diabetes, but two critical challenges face the field: 1 …