The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules

SJ Archibald, L Allott - EJNMMI radiopharmacy and chemistry, 2021 - Springer
Abstract The aluminium-[18F] fluoride ([18F] AlF) radiolabelling method combines the
favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal …

A Comprehensive Review of Non-Covalent Radiofluorination Approaches Using Aluminum [18F]fluoride: Will [18F]AlF Replace 68Ga for Metal Chelate Labeling?

C Fersing, A Bouhlel, C Cantelli, P Garrigue… - Molecules, 2019 - mdpi.com
Due to its ideal physical properties, fluorine-18 turns out to be a key radionuclide for positron
emission tomography (PET) imaging, for both preclinical and clinical applications. However …

A general [18 F] AlF radiochemistry procedure on two automated synthesis platforms

L Allott, C Da Pieve, DR Turton, G Smith - Reaction Chemistry & …, 2017 - pubs.rsc.org
The aluminium fluoride-18 ([18F] AlF) radiolabelling procedure has generated great interest
because it is a simple, one-pot method that can be used to directly radiolabel small …

Radiochemistry with {Al18F} 2+: Current status and optimization perspectives for efficient radiofluorination by complexation

S Schmitt, E Moreau - Coordination Chemistry Reviews, 2023 - Elsevier
With the aim to efficiently develop and synthesize new radiotracers for PET imaging, and
their use for theranostic approaches, radiolabeling technics have not ceased to progress …

Fluorine-18: A radionuclide with diverse range of radiochemistry and synthesis strategies for target based PET diagnosis

NS Goud, RK Joshi, RD Bharath, P Kumar - European Journal of Medicinal …, 2020 - Elsevier
Fluorine-18 is one of the most widely used radionuclides for the production of
radiopharmaceuticals for positron emission tomography (PET). The radiolabeling methods …

Fluorine-18 radiochemistry, labeling strategies and synthetic routes

O Jacobson, DO Kiesewetter, X Chen - Bioconjugate chemistry, 2015 - ACS Publications
Fluorine-18 is the most frequently used radioisotope in positron emission tomography (PET)
radiopharmaceuticals in both clinical and preclinical research. Its physical and nuclear …

New Chelators for Low Temperature Al18F-Labeling of Biomolecules

F Cleeren, J Lecina, EMF Billaud… - Bioconjugate …, 2016 - ACS Publications
The Al18F labeling method is a relatively new approach that allows radiofluorination of
biomolecules such as peptides and proteins in a one-step procedure and in aqueous …

[18 F]-Group 13 fluoride derivatives as radiotracers for positron emission tomography

K Chansaenpak, B Vabre, FP Gabbaï - Chemical Society Reviews, 2016 - pubs.rsc.org
The field of 18F chemistry is rapidly expanding because of the use of this radionuclide in
radiotracers for positron emission tomography (PET). Until recently, most [18F]-radiotracers …

New Strategies for Rapid 18F-Radiolabeling of Biomolecules for Radionuclide-Based In Vivo Imaging

JL Zeng, J Wang, JA Ma - Bioconjugate chemistry, 2015 - ACS Publications
The increasing availability of highly active no-carrier-added [18F]-fluoride makes its use in
radiolabeling biomolecules attractive. By incorporating “fluorophilic” elements (Si, B, and Al) …

Al18F labeling of peptides and proteins

P Laverman, WJ McBride, RM Sharkey… - Journal of Labelled …, 2014 - Wiley Online Library
Radiolabeled receptor‐binding peptides and proteins have emerged as an important class
of radiopharmaceuticals that have changed radionuclide imaging in clinical practice. Many …