[HTML][HTML] Gut microbial metabolite butyrate and its therapeutic role in inflammatory bowel disease: a literature review

N Recharla, R Geesala, XZ Shi - Nutrients, 2023 - mdpi.com
Background and objective: Inflammatory bowel disease (IBD), including Crohn's disease
and ulcerative colitis, is a chronic inflammatory disorder characterized by aberrant immune …

Protective mechanisms of butyrate on inflammatory bowel disease

JPB Silva, KC Navegantes-Lima… - Current …, 2018 - ingentaconnect.com
Inflammatory bowel disease (IBD) is a multifactorial chronic disease, commonly associated
with alteration in the composition and function of gut microbiota. This process can lead to a …

[HTML][HTML] Butyrate and the fine-tuning of colonic homeostasis: implication for inflammatory bowel diseases

N Gasaly, MA Hermoso, M Gotteland - International journal of molecular …, 2021 - mdpi.com
This review describes current evidence supporting butyrate impact in the homeostatic
regulation of the digestive ecosystem in health and inflammatory bowel diseases (IBDs) …

[HTML][HTML] Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease

K Hodgkinson, F El Abbar, P Dobranowski… - Clinical Nutrition, 2023 - Elsevier
Butyrate is a key energy source for colonocytes and is produced by the gut microbiota
through fermentation of dietary fiber. Butyrate is a histone deacetylase inhibitor and also …

The immunomodulatory functions of butyrate

MT Siddiqui, GAM Cresci - Journal of inflammation research, 2021 - Taylor & Francis
The gastrointestinal (GI) system contains many different types of immune cells, making it a
key immune organ system in the human body. In the last decade, our knowledge has …

Microbiota-derived butyrate regulates intestinal inflammation: Focus on inflammatory bowel disease

MR Couto, P Gonçalves, F Magro, F Martel - Pharmacological Research, 2020 - Elsevier
Inflammatory bowel disease (IBD) refers to a group of heterogeneous disorders associated
with chronic inflammation of the gut, having a high rate of incidence in the world. In the …

Oral administration of sodium butyrate attenuates inflammation and mucosal lesion in experimental acute ulcerative colitis

ELM Vieira, AJ Leonel, AP Sad, NRM Beltrão… - The Journal of nutritional …, 2012 - Elsevier
Butyrate is a four-carbon short-chain fatty acid that improves colonic trophism. Although
several studies have shown the benefits of butyrate enemas in ulcerative colitis (UC) …

Intestinal inflammation modulates the epithelial response to butyrate in patients with inflammatory bowel disease

E Ferrer-Picón, I Dotti, AM Corraliza… - Inflammatory bowel …, 2020 - academic.oup.com
Background Butyrate-producing gut bacteria are reduced in patients with active
inflammatory bowel disease (IBD), supporting the hypothesis that butyrate supplementation …

[HTML][HTML] Implications of butyrate and its derivatives for gut health and animal production

A Bedford, J Gong - Animal Nutrition, 2018 - Elsevier
Butyrate is produced by microbial fermentation in the large intestine of humans and animals.
It serves as not only a primary nutrient that provides energy to colonocytes, but also a …

The role of butyrate on colonic function

HM Hamer, D Jonkers, K Venema… - Alimentary …, 2008 - Wiley Online Library
Background Butyrate, a short‐chain fatty acid, is a main end‐product of intestinal microbial
fermentation of mainly dietary fibre. Butyrate is an important energy source for intestinal …