Postmortem cortical transcriptomics of Lewy body dementia reveal mitochondrial dysfunction and lack of neuroinflammation
Abstract Objective Prevalence of Lewy body dementias (LBD) is second only to Alzheimer's
disease (AD) among people with neurodegenerative dementia. LBD cause earlier mortality …
disease (AD) among people with neurodegenerative dementia. LBD cause earlier mortality …
Systematic review of gene expression studies in people with Lewy body dementia
A Chowdhury, AP Rajkumar - Acta Neuropsychiatrica, 2020 - cambridge.org
Objectives: Lewy body dementia (LBD) is the second most prevalent neurodegenerative
dementia and it causes more morbidity and mortality than Alzheimer's disease. Several …
dementia and it causes more morbidity and mortality than Alzheimer's disease. Several …
Gene expression profiling of brain samples from patients with Lewy body dementia
Abstract Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative
disorder in the elderly. The development and progression of DLB remain unclear. In this …
disorder in the elderly. The development and progression of DLB remain unclear. In this …
Next-generation RNA-sequencing of serum small extracellular vesicles discovers potential diagnostic biomarkers for dementia with Lewy bodies
AP Rajkumar, A Hye, J Lange, YR Manesh… - The American Journal of …, 2021 - Elsevier
Objective There is an urgent clinical need for identifying blood-based diagnostic biomarkers
for Dementia with Lewy Bodies (DLB). Transcriptomic studies have reported unique RNA …
for Dementia with Lewy Bodies (DLB). Transcriptomic studies have reported unique RNA …
Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer's disease and Parkinson's disease: a large-scale multi-trait …
P Guo, W Gong, Y Li, L Liu, R Yan, Y Wang, Y Zhang… - BMC medicine, 2022 - Springer
Background The current genome-wide association study (GWAS) of Lewy body dementia
(LBD) suffers from low power due to a limited sample size. In addition, the genetic …
(LBD) suffers from low power due to a limited sample size. In addition, the genetic …
Cross-platform transcriptional profiling identifies common and distinct molecular pathologies in Lewy body diseases
R Feleke, RH Reynolds, AM Smith, B Tilley… - Acta …, 2021 - Springer
Abstract Parkinson's disease (PD), Parkinson's disease with dementia (PDD) and dementia
with Lewy bodies (DLB) are three clinically, genetically and neuropathologically overlapping …
with Lewy bodies (DLB) are three clinically, genetically and neuropathologically overlapping …
Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer's disease
Background Based on amyloid cascade and tau hypotheses, protein biomarkers of different
Aβ and tau species in cerebrospinal fluid (CSF) and blood/plasma/serum have been …
Aβ and tau species in cerebrospinal fluid (CSF) and blood/plasma/serum have been …
Systematic review of genetic association studies in people with Lewy body dementia
H Sanghvi, R Singh, H Morrin… - International Journal of …, 2020 - Wiley Online Library
Objectives Lewy body dementia (LBD) causes more morbidity, disability, and earlier
mortality than Alzheimer disease. Molecular mechanisms underlying neurodegeneration in …
mortality than Alzheimer disease. Molecular mechanisms underlying neurodegeneration in …
[HTML][HTML] Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across …
Neurodegenerative disorders such as Alzheimer's disease (AD), Lewy body diseases (LBD),
and the amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) spectrum are …
and the amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) spectrum are …
[HTML][HTML] From protein biomarkers to proteomics in dementia with Lewy Bodies
A Tsamourgelis, P Swann, L Chouliaras… - Ageing Research …, 2023 - Elsevier
Abstract Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative
dementia. Despite considerable research progress, there remain gaps in our understanding …
dementia. Despite considerable research progress, there remain gaps in our understanding …