Postmortem cortical transcriptomics of Lewy body dementia reveal mitochondrial dysfunction and lack of neuroinflammation

AP Rajkumar, G Bidkhori, S Shoaie, E Clarke… - The American Journal of …, 2020 - Elsevier
Abstract Objective Prevalence of Lewy body dementias (LBD) is second only to Alzheimer's
disease (AD) among people with neurodegenerative dementia. LBD cause earlier mortality …

Systematic review of gene expression studies in people with Lewy body dementia

A Chowdhury, AP Rajkumar - Acta Neuropsychiatrica, 2020 - cambridge.org
Objectives: Lewy body dementia (LBD) is the second most prevalent neurodegenerative
dementia and it causes more morbidity and mortality than Alzheimer's disease. Several …

Gene expression profiling of brain samples from patients with Lewy body dementia

M Pietrzak, A Papp, A Curtis, SK Handelman… - Biochemical and …, 2016 - Elsevier
Abstract Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative
disorder in the elderly. The development and progression of DLB remain unclear. In this …

Next-generation RNA-sequencing of serum small extracellular vesicles discovers potential diagnostic biomarkers for dementia with Lewy bodies

AP Rajkumar, A Hye, J Lange, YR Manesh… - The American Journal of …, 2021 - Elsevier
Objective There is an urgent clinical need for identifying blood-based diagnostic biomarkers
for Dementia with Lewy Bodies (DLB). Transcriptomic studies have reported unique RNA …

Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer's disease and Parkinson's disease: a large-scale multi-trait …

P Guo, W Gong, Y Li, L Liu, R Yan, Y Wang, Y Zhang… - BMC medicine, 2022 - Springer
Background The current genome-wide association study (GWAS) of Lewy body dementia
(LBD) suffers from low power due to a limited sample size. In addition, the genetic …

Cross-platform transcriptional profiling identifies common and distinct molecular pathologies in Lewy body diseases

R Feleke, RH Reynolds, AM Smith, B Tilley… - Acta …, 2021 - Springer
Abstract Parkinson's disease (PD), Parkinson's disease with dementia (PDD) and dementia
with Lewy bodies (DLB) are three clinically, genetically and neuropathologically overlapping …

Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer's disease

H Wang, KK Dey, PC Chen, Y Li, M Niu, JH Cho… - Molecular …, 2020 - Springer
Background Based on amyloid cascade and tau hypotheses, protein biomarkers of different
Aβ and tau species in cerebrospinal fluid (CSF) and blood/plasma/serum have been …

Systematic review of genetic association studies in people with Lewy body dementia

H Sanghvi, R Singh, H Morrin… - International Journal of …, 2020 - Wiley Online Library
Objectives Lewy body dementia (LBD) causes more morbidity, disability, and earlier
mortality than Alzheimer disease. Molecular mechanisms underlying neurodegeneration in …

[HTML][HTML] Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across …

A Noori, AM Mezlini, BT Hyman, A Serrano-Pozo… - Neurobiology of …, 2021 - Elsevier
Neurodegenerative disorders such as Alzheimer's disease (AD), Lewy body diseases (LBD),
and the amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) spectrum are …

[HTML][HTML] From protein biomarkers to proteomics in dementia with Lewy Bodies

A Tsamourgelis, P Swann, L Chouliaras… - Ageing Research …, 2023 - Elsevier
Abstract Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative
dementia. Despite considerable research progress, there remain gaps in our understanding …