Objective.—To maximize deposition of an aerosolized dose of insulin (mean±SD=
0.99±0.06 U/kg of body weight) in the lungs of subjects with non—insulin-dependent …

Inhalation of regular insulin for meal time glucose control has been found to be safe,
efficacious and reliable in Type I and Type II diabetics. The administration of regular insulin …

Seven fasting patients with noninsulin-dependent diabetes mellitus (NIDDM) inhaled 1.0
U/kg of body weight of nebulized regular pork insulin by mouth or were subcutaneously (sc) …

We compared the pharmacodynamics of insulin after inhalation of 99 U microcrystalline
solid insulin and subcutaneous injection of 10 U regular insulin and intravenous injection of …

Targeted glycemic control in patients with type 1 and type 2 diabetes is grossly inadequate,
despite data demonstrating reduced microvascular and macrovascular diabetic …

The most promising alternative route of insulin administration seems to be pulmonary
delivery by inhalation. For a maximal rate of absorption insulin must be applied deep into the …

Purpose. Pharmacokinetic and safety data related to the use of inhaled insulin for the
management of diabetes mellitus are discussed. The various pulmonary insulin delivery …

Objectives. To study the biological effects of nebulized insulin, administered intrapulmonary,
to healthy volunteers. Design. A double‐blind, randomized, controlled intervention study …

Background: Despite demonstrated benefits, intensive insulin therapy has not gained
widespread clinical acceptance for several reasons: Multiple daily injections are …

Inhalation is a potentially viable route of insulin administration. This treatment is being tested
but has not been approved by the United States Food and Drug Administration (FDA). The …