The associations of tricyclic antidepressants (TCAs) with reduced incidence of gliomas and
elevated autophagy in glioma cells motivated investigation in mouse models of …

Although autophagy enhances cell survival in nutrient-deprived cells by increasing
adenosine triphosphate (ATP) production, it remains unclear if autophagy functions similarly …

Although the phosphatidylinositol 3-kinase to Akt to mammalian target of rapamycin (PI3K-
Akt-mTOR) pathway promotes survival signaling, inhibitors of PI3K and mTOR induce …

Autophagy is a well-described degradation mechanism that promotes cell survival upon
nutrient starvation and other forms of cellular stresses. In addition, there is growing evidence …

In this review we analyze the ability of antipsychotic medications to modulate
macroautophagy, a process of controlled lysosomal digestion of cellular macromolecules …

Increasing evidence suggests that induction of lethal macroautophagy/autophagy carries
potential significance for the treatment of glioblastoma (GBM). In continuation of previous …

Glioblastoma multiforme (GBM) has a poor prognosis with an overall survival of 14–15
months after surgery, radiation and chemotherapy using temozolomide (TMZ). A major …

Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent
high-grade gliomas. However, the efficacy of TMZ is often limited by the development of …

In this study, we investigated the antitumor effects of the tricyclic antidepressant 3-(10, 11-
dihydro-5H-dibenzo [b, f] azepin-5-yl)-N, N-dimethylpropan-1-amine (imipramine) on glioma …

Glioblastoma (GBM) is the most aggressive primary brain tumor, exhibiting a high rate of
recurrence and poor prognosis. Surgery and chemoradiation with temozolomide (TMZ) …