Adenosine is a ubiquitous extracellular signaling molecule with essential functions in human
physiology. Due to the widespread expression of adenosine receptors, it has far-reaching …

Adenosine is an ubiquitous extracellular signaling molecule and plays a fundamental role in
the regulation of coronary microcirculation through activation of adenosine receptors (ARs) …

Adenosine is a nucleoside that impacts the cardiovascular system via the activation of its
membrane receptors, named A1R, A2AR, A2BR and A3R. Adenosine is released during …

Endogenous adenosine is produced by the heart during ischemia-reperfusion as a natural
cardioprotectant. The benefits of this local protective mechanism can be harnessed by …

Adenosine is known to regulate myocardial and coronary circulatory functions. Adenosine
not only dilates coronary vessels, but attenuates beta-adrenergic receptor-mediated …

The purine nucleoside adenosine is an important regulator within the cardiovascular system,
and throughout the body. Released in response to perturbations in energy state, among …

Adenosine is an endogenous nucleoside with a short half-life that regulates many
physiological functions involving the heart and cardiovascular system. Among the …

Objectives The present study sought to establish the dosage of intracoronary (IC) adenosine
associated with minimal side effects and above which no further increase in flow can be …

Intra-and extracellular adenosine levels rise in response to physiological stimuli and with
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …

Adenosine is an autacoid that plays a critical role in regulating cardiac function, including
heart rate, contractility, and coronary flow. In this chapter, current knowledge of the functions …