Neuromyelitis optica spectrum disorders (NMOSDs) are caused by immunoglobulin G (IgG)
autoantibodies directed against the water channel aquaporin-4 (AQP4). In NMOSDs …

Neuromyelitis optica (NMO) is an autoimmune CNS disorder mediated by pathogenic
aquaporin-4 (AQP4) water channel autoantibodies (AQP4-IgG). Although AQP4-IgG–driven …

Background Neuromyelitis optica (NMO) is a severe demyelinating disorder of the central
nervous system (CNS) associated with the presence of an autoimmune antibody response …

Abstract Autoantibodies to aquaporin-4 (AQP4) are pathogenic in neuromyelitis optica
spectrum disorder (NMOSD). However, it is not known which B cells are the major …

Neuromyelitis optica (NMO) is the first inflammatory autoimmune demyelinating disease of
the CNS for which a specific tissue target molecule has been identified—the astrocytic water …

Abstract Background In 70-80% of cases, neuromyelitis optica (NMO) is associated with
highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG) …

Objectives Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory
disorder of the central nervous system (CNS) targeted against aquaporin‐4 (AQP4). The …

Neuromyelitis optica spectrum disorders (NMOSD) are central nervous system inflammatory
disorders causing significant morbidities and mortality. The majority of NMOSD patients …

The astrocytic aquaporin-4 (AQP4) water channel is the target of pathogenic antibodies in a
spectrum of relapsing autoimmune inflammatory central nervous system disorders of varying …

Introduction: Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory
demyelinating disease of the central nervous system affecting primarily the spinal cord and …