Last year was the 10th anniversary of Ralph Steinman's Nobel Prize awarded for his
discovery of dendritic cells (DCs), while next year brings the 50th anniversary of that …

We previously described a mechanism for the maintenance of peripheral self-tolerance. This
involves the cross-presentation of tissue-associated antigens by a bone marrow–derived …

The Problem: Tumor Immunity Is Not Effectively Induced in Tumor-bearing Hosts. Animal
experiments as well as clinical experience, notably in melanoma, indicate that the immune …

A recent workshop on" Dendritic Cells: Biology and Therapeutic Applications," sponsored by
the Juan March Foundation, brought together basic and clinical research scientists to …

The immune system generally avoids horror autotoxicus or autoimmunity, an attack against
the body's own constituents. This avoidance requires that self-reactive T cells be actively …

Ralph Steinman was posthumously awarded a Nobel Prize in 2011 “for his discovery of the
dendritic cell and its role in adaptive immunity.” He first coined the term “dendritic cell” in …

Although we normally think of dendritic cells (DCs; references 1 and 2) as the “initiators” of
immune responses and of their activity as confined largely to interaction with naive T cells in …

The immune response to T helper (Th) cell determinants of a variety of antigens is often poor
and limits severely the potential efficacy of current therapeutic measures through …

Dendritic cells (DCs) need activation for the priming of antigen-specific immune responses.
Recently activated DCs were described to prime in vitro strong T helper cell type 1 (Th1) …

The study of dendritic cells (DCs) has seen a rapid expansion in recent years, and their
importance within the immune system is now widely recognized. Along with B lymphocytes …