Previously, we found that the 5-HT 2A receptor plays a key role in cell injury. However, the
mechanism by which the 5-HT 2A receptor mediates intracellular processes remains …

Previously we found that acute liver injury (ALI) with inflammation caused by carbon
tetrachloride (CCl 4) was associated with the activation of the 5-HT degradation system …

hydroxytryptamine (5-HT) is involved in the pathological processes of several liver diseases.
Acute liver injury underlies the development of many liver diseases, but the mechanism …

Background/Aims: Previously, we confirmed that liver-synthesized 5-HT rather than non-liver
5-HT, acting on the 5-HT 2 receptor (5-HT 2 R), modulates lipid-induced excessive lipid …

Background and aim Hepatocellular cancer (HCC) is the sixth most common cancer and
liver fibrosis is strongly associated with HCC. Treatment options are limited, and preventive …

We investigated the effects of two 5-HT6 receptor antagonists on rat primary hepatocytes
using a combined biochemical and toxicogenomics approach. Both compounds share the …

In the present study we investigated the role of 5-hydroxytryptamine (5-HT) and 5-HT 1A
receptor during liver regeneration after partial hepatectomy (PH) and N-nitrosodiethylamine …

The serotonin 6 receptor (5-HT6R) is one of the most recently cloned receptors among the
known serotonin receptors. Because it is abundantly distributed in the limbic region and is …

Background Serotonin exhibits a vast repertoire of actions including cell proliferation and
differentiation. The effect of serotonin, as an incomplete mitogen, on liver regeneration has …

5-hydroxytryptamine type 3 (5-HT3) receptors are ligand gated ion channels, which clearly
distinguish their mode of action from the other G-protein coupled 5-HT or serotonin …