The neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule in
the brain and in pancreatic islets. Here, we demonstrate that GABA regulates cytokine …

Abstract γ-Aminobutyric acid (GABA) is both a major inhibitory neurotransmitter in the CNS
and a product of β cells of the peripheral islets. Our previous studies, and those of others …

Type 1 diabetes (T1D) is an autoimmune disease characterized by insulitis and islet β-cell
loss. Thus, an effective therapy may require β-cell restoration and immune suppression …

γ-Aminobutyric acid (GABA) exerts protective and regenerative effects on mouse islet β-
cells. However, in humans it is unknown whether it can increase β-cell mass and improve …

OBJECTIVE Paracrine signaling via γ-aminobutyric acid (GABA) and GABAA receptors
(GABAARs) has been documented in rodent islets. Here we have studied the importance of …

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain.
However, it is also produced in other sites; notably by pancreatic β cells and immune cells …

Background: Diabetes mellitus (DM) is an endocrine disorder characterized by
hyperglycemia, polyuria, polydipsia, and glucosuria. γ-aminobutyric acid (GABA) is an …

GABA (γ-aminobutyric acid), the main inhibitory neurotransmitter in the central nervous
system is also present in the pancreatic islet β cells where it may function as a paracrine …

Background We recently found that γ-aminobutyric acid (GABA) protects mouse islet β cells.
It prevented autoimmune type 1 diabetes in mice, induced islet β-cell regeneration, and …

As a well-known inhibitory neurotransmitter in the central nervous system, gamma-
aminobutyric acid also has critical roles in immune system. Immune cells (eg, lymphocytes …