The development of resistance to sulfadoxine-pyrimethamine by Plasmodium parasites is a
major problem for the effective treatment of malaria, especially P. falciparum malaria …

Resistance of Plasmodium falciparum to the antimalarial drug sulfadoxine–pyrimethamine is
a result of extremely rare mutations that have spread over large geographical areas. This …

The sulfonamide and sulfone (sulfa) group of antimalarials has been used extensively
throughout malaria endemic regions of the world to control this important infectious disease …

Chemotherapy remains the only practicable tool to control falciparum malaria in sub-
Saharan Africa, where> 90% of the world's burden of malaria mortality and morbidity occurs …

The antifolate combination of pyrimethamine (PM) and sulfadoxine (SD) is the last affordable
drug combination available for wide-scale treatment of falciparum malaria in Africa …

Clones of Plasmodium falciparum prepared from recent isolates of infected blood were
studied to determine the molecular mechanism of naturally occurring pyrimethamine …

In vitro sulfadoxine and pyrimethamine resistance has been associated with point mutations
in the dihydropteroate synthase and dihydrofolate reductase domains, respectively, but the …

Drug resistance is contributing to increasing mortality from malaria worldwide. For
assessment of the role of resistance-conferring parasite mutations on treatment responses to …

Antimalarial chemotherapy is one of the main pillars in the prevention and control of malaria.
Following widespread resistance of Plasmodium falciparum to chloroquine, sulfadoxine …

Recent studies indicated that sensitive parasites could increase in frequency in a population
when drugs are removed, suggesting that the life span of affordable antimalarial drugs could …