Mitochondrial dynamics and its involvement in disease

DC Chan - Annual review of pathology: mechanisms of disease, 2020 - annualreviews.org
The dynamic properties of mitochondria—including their fusion, fission, and degradation—
are critical for their optimal function in energy generation. The interplay of fusion and fission …

Mitochondrial dynamics—mitochondrial fission and fusion in human diseases

SL Archer - New England Journal of Medicine, 2013 - Mass Medical Soc
Mitochondria fuse and divide in response to cell demands and environment. Alterations in
mitochondrial dynamics underlie various human diseases, including cancer and neurologic …

Mitochondrial dynamics in health and disease

NMB Yapa, V Lisnyak, B Reljic, MT Ryan - FEBS letters, 2021 - Wiley Online Library
In animals, mitochondria are mainly organised into an interconnected tubular network
extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as …

Mitochondrial fusion and fission in cell life and death

B Westermann - Nature reviews Molecular cell biology, 2010 - nature.com
Mitochondria are dynamic organelles that constantly fuse and divide. These processes
(collectively termed mitochondrial dynamics) are important for mitochondrial inheritance and …

Molecular mechanisms and physiologic functions of mitochondrial dynamics

H Otera, K Mihara - The journal of biochemistry, 2011 - academic.oup.com
Mitochondria are highly dynamic organelles that continuously change their shape through
frequent fusion, fission and movement throughout the cell, and these dynamics are crucial …

[HTML][HTML] New insights into the function and regulation of mitochondrial fission

H Otera, N Ishihara, K Mihara - … et Biophysica Acta (BBA)-Molecular Cell …, 2013 - Elsevier
Mitochondrial morphology changes dynamically by coordinated fusion and fission and
cytoskeleton-based transport. Cycles of outer and inner membrane fusion and fission are …

Mitochondria: from cell death executioners to regulators of cell differentiation

A Kasahara, L Scorrano - Trends in cell biology, 2014 - cell.com
Most, if not all mitochondrial functions, including adenosine-5′-triphosphate (ATP)
production and regulation of apoptosis and Ca 2+ homeostasis, are inextricably linked to …

Mitochondrial dynamics and their potential as a therapeutic target

BN Whitley, EA Engelhart, S Hoppins - Mitochondrion, 2019 - Elsevier
Mitochondrial dynamics shape the mitochondrial network and contribute to mitochondrial
function and quality control. Mitochondrial fusion and division are integrated into diverse …

Mitochondrial dynamics in mitochondrial diseases

JM Suárez-Rivero, M Villanueva-Paz… - Diseases, 2016 - mdpi.com
Mitochondria are very versatile organelles in continuous fusion and fission processes in
response to various cellular signals. Mitochondrial dynamics, including mitochondrial …

Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity

AM Bertholet, T Delerue, AM Millet, MF Moulis… - Neurobiology of …, 2016 - Elsevier
Mitochondria are dynamic organelles that continually move, fuse and divide. The dynamic
balance of fusion and fission of mitochondria determines their morphology and allows their …