Cancer is a borderless global health challenge that continues to threaten human health.
Studies have found that oxidative stress (OS) is often associated with the etiology of many …

Abstract The Nrf2/Keap1 pathway is an important signaling cascade responsible for the
resistance of oxidative damage induced by exogenous chemicals. It maintains the redox …

Background Nrf2 regulates oxidative stress, which is essential for cellular function.
Fundamental initiation of Nrf2 in many malignancies increases prosurvival genes & …

Nrf2 is a transcription factor that stimulates the expression of genes which have antioxidant
response element-like sequences in their promoter. Nrf2 is a cellular protector, and this …

Nuclear factor E2-related factor 2 (NRF2) plays an important role in redox metabolism and
antioxidant defense. Under normal conditions, NRF2 proteins are maintained at very low …

NRF2 has been traditionally considered as a tumor suppressor because its cytoprotective
functions are deemed to be the main cellular defense mechanism against exogenous and …

In response to oxidative stress, the transcription factor NF-E2-related factor 2 (Nrf2) controls
the fate of cells through transcriptional upregulation of antioxidant response element (ARE) …

Nuclear factor-erythroid 2-related factor 2 (NRF2) is a master regulator of a series of
cytoprotective genes, which protects cells from stress conditions such as reactive oxygen …

Chemotherapy and chemoprevention have been two of the most important means to control
cancer incidence and mortality, and the cellular defensive machinery against …

The oxidative balance of a cell is maintained by the Kelch-like ECH-associated protein 1
(KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway. This cytoprotective …