NF-κB is a key transcription factor that regulates innate immune response. Its activity is
tightly controlled by numerous feedback loops, including two negative loops mediated by NF …

Mammalian inflammatory signaling, for which NF‐κB is a principal transcription factor, is an
exquisite example of how cellular signaling pathways can be regulated to produce different …

The mathematical modeling of the NF-κ B oscillations has attracted considerable attention in
recent times, but there is a lack of simple models in the literature that can capture the main …

The transcription factor NF‐κB (p65/p50) plays a central role in the coordination of cellular
responses by activating the transcription of numerous target genes. The precise role of the …

NF-κB signaling is known to be critically regulated by the NF-κB–inducible inhibitor protein
IκBα. The resulting negative feedback has been shown to produce a propensity for …

Mathematical modeling has proved to be a critically important approach in the study of many
complex networks and dynamic systems in physics, engineering, chemistry, and biology …

White's lab established that strong, continuous stimulation with tumour necrosis factor-α
(TNFα) can induce sustained oscillations in the subcellular localisation of the transcription …

Abstract Background The NF-κ B regulatory network controls innate immune response by
transducing variety of pathogen-derived and cytokine stimuli into well defined single-cell …

Nuclear factor (NF)-κB controls the transcriptional response to inflammatory signals by
translocating into the nucleus, but we lack a single-cell characterization of the resulting …

Transcription factor nuclear factor kappa B (NF-κB) shows cooperative switch-like activation
followed by prolonged oscillatory nuclear translocation in response to extracellular stimuli …