Objective: Despite several decades of research, there is still uncertainty regarding the
optimal lithium dosage regimen associated with a decreased risk of renal effects, such as …

For over half a century, it has been widely known that lithium is the most efficacious
maintenance treatment for bipolar disorder. Despite thorough research on the long-term …

Lithium has been the most effective psychopharmacological drug in the long-term treatment
of patients with recurrent unipolar and bipolar affective illness. As a result of its widespread …

Bipolar disorder is a recurrent chronic illness distinguished by periods of mania and
depression. Lithium has been used for about 60 years as a 'mood stabilizer'for bipolar …

Background: This study compared the largest set of bipolar disorder pharmacotherapies to
date (71 drugs and drug combinations) for risk of kidney disorders (KDs). Methods: This …

Introduction Lithium is established as an effective treatment of mania, of depression in
bipolar and unipolar disorder, and in maintenance treatment of these disorders. However …

Objective This study was designed to determine whether patients maintained on a regimen
of lithium on a once-per-day schedule have lower urine volumes than do patients receiving …

Lithium has been reported to induce polyuria in up to 35% of patients receiving it. It has
been suggested that polyuria may be reduced by using single rather than multiple daily …

Werneke U, Ott M, Salander Renberg E, Taylor D, Stegmayr B. A decision analysis of long‐
term lithium treatment and the risk of renal failure. Objective: To establish whether lithium or …

Objectives Polyuria increases the risk of dehydration and lithium toxicity in lithium‐treated
patients. Risk factors have been inconsistently described and the variance of this adverse …